Vasoactive intestinal peptide is a local mediator in a gut-brain neural axis activating intestinal gluconeogenesis
| العنوان: | Vasoactive intestinal peptide is a local mediator in a gut-brain neural axis activating intestinal gluconeogenesis |
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| المؤلفون: | Amandine Gautier-Stein, F. Plessier, Gilles Mithieux, F. De Vadder |
| المساهمون: | Di Carlo, Marie-Ange, Université de Lyon, Nutrition et cerveau (U1213, U855), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), The authors thank the CNRS (G.M.), the INRA (A.G.-S.), the Ministère de l’Enseignement Supérieur et de la Recherche (F.D.V.), and the Ecole Normale Supérieure de Lyon (F.P.) for funding their positions. This work was funded by the INSERM. |
| المصدر: | Neurogastroenterology & Motility Neurogastroenterology & Motility, Wiley, 2015, 27 (3), pp.443-448. ⟨10.1016/j.molmet.2014.12.009⟩ |
| بيانات النشر: | HAL CCSD, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Receptors, Vasoactive Intestinal Polypeptide, Type I, Physiology, Vasoactive intestinal peptide, Gut–brain axis, Enteric Nervous System, Rats, Sprague-Dawley, Mediator, In vivo, Internal medicine, Intestinal gluconeogenesis, medicine, Animals, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Gene, vasoactive intestinal peptide, Neurons, chemistry.chemical_classification, biology, Endocrine and Autonomic Systems, gut-brain axis, Gluconeogenesis, Gastroenterology, glucose-6- phosphatase KEY MESSAGES, Jejunum, Endocrinology, chemistry, Glucose-6-Phosphatase, biology.protein, Propionate, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Antagonism, Glucose 6-phosphatase |
| الوصف: | Intestinal gluconeogenesis (IGN) promotes metabolic benefits through activation of a gut-brain neural axis. However, the local mediator activating gluconeogenic genes in the enterocytes remains unknown. We show that (i) vasoactive intestinal peptide (VIP) signaling through VPAC1 receptor activates the intestinal glucose-6-phosphatase gene in vivo, (ii) the activation of IGN by propionate is counteracted by VPAC1 antagonism, and (iii) VIP-positive intrinsic neurons in the submucosal plexus are increased under the action of propionate. These data support the role of VIP as a local neuromodulator released by intrinsic enteric neurons and responsible for the induction of IGN through a VPAC1 receptor-dependent mechanism in enterocytes. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1350-1925 1365-2982 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ab54f7f21a8b12ae7533adc29c444e https://www.hal.inserm.fr/inserm-01350922/document |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....27ab54f7f21a8b12ae7533adc29c444e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13501925 13652982 |
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