The amphioxus genome illuminates vertebrate origins and cephalochordate biology
| العنوان: | The amphioxus genome illuminates vertebrate origins and cephalochordate biology |
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| المؤلفون: | Kazutoyo Osoegawa, Finn Hallböök, Kazuyoshi Hosomichi, Hidetoshi Inoko, Naohito Takatori, Masanobu Satake, Jeremy J. Gibson-Brown, Christian M. Zmasek, Yasunori Sasakura, Yutaka Satou, Kaoru Azumi, Linda Z. Holland, Anlong Xu, Peter W. H. Holland, Zeev Pancer, Masaru Nonaka, Dan Hirose, Noriyuki Satoh, Carmela Gissi, Adam Godzik, Alice C. McHardy, Takashi Shiina, Masanori Kasahara, Takeshi Kawashima, Zbynek Kozmik, Graeme J. Roch, Larry J. Dishaw, Simona Candiani, Nancy M. Sherwood, Jordi Garcia-Fernàndez, Jun Kasamatsu, Len A. Pennacchio, Mario Pestarino, Qing Zhang, Nicholas H. Putnam, Marianne Bronner-Fraser, Shuichi Wada, Fumiko Yoshizaki, Isidore Rigoutsos, Daniel S. Rokhsar, Frédéric Brunet, Hidetoshi Saiga, Keita Yoshida, Robert Piotr Olinski, Marc Robinson-Rechavi, Èlia Benito-Gutiérrez, Masaaki Kobayashi, Thomas Butts, Kaoru Kubokawa, David E. K. Ferrier, Ayuko Kimura, Daniel Meulemans, Gary W. Litman, Tetsuro Ikuta, Ricard Albalat, Jonathan P. Rast, Vincent Laudet, Michael Schubert, Matthew J. Blow, Pavel Vopalensky, Yuzhen Ye, Pieter J. de Jong, Jr-Kai Yu, Javier Tello |
| المساهمون: | Marine Biology Research Division, University of California [San Diego] (UC San Diego), University of California-University of California-Scripps Institution of Oceanography, University of Barcelona, Hokkaido University [Sapporo, Japan], United States Department of Energy, California Institute of Technology (CALTECH), Institut de Génomique Fonctionnelle de Lyon (IGFL), École normale supérieure - Lyon (ENS Lyon)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Department of Zoology, University of Cambridge [UK] (CAM), Dipartimento di Biologia, Universita degli studi di Genova, H. Lee Moffitt Cancer Center and Research Institute, All Children’s Hospital, University of St Andrews [Scotland], Department of Biology, Washington University in Saint Louis (WUSTL), Institute for Evolutionary Discovery, Partenaires INRAE, Università degli studi di Milano [Milano], Sanford Burnham Prebys Medical Discovery Institute, Uppsala University, Tokyo Metropolitan University, Tokai University School of Medicine, Hokkaido University Graduate School of Medicine, University Graduate School of Medicine, University of California [Berkeley], University of California, Okinawa Institute of Science and Technology Graduate University (OIST), The University of Tokyo, Institute of Molecular Genetics of the Czech Academy of Sciences (IMG / CAS), Czech Academy of Sciences [Prague] (CAS), University of South Florida (USF), IBM Thomas J. Watson Research Center, Max Planck Institute for Computer Science, University of Maryland Biotechnology Institute, University of Toronto, Université de Lausanne (UNIL), Northern Arizona University [Flagstaff], Shimoda Marine Research Center, University of Tsukuba, Tohoku University [Sendai], Kyoto University [Kyoto], Osaka University, Nagahama Institute of Bio-Science and Technology, Sun Yat-Sen University [Guangzhou] (SYSU), Juntendo University, Children's Hospital Oakland Research Institute |
| المصدر: | Genome Research Genome Research, Cold Spring Harbor Laboratory Press, 2008, 18 (7), pp.1100-1111. ⟨10.1101/gr.073676.107⟩ |
| بيانات النشر: | Cold Spring Harbor Lab Press, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Branchiostoma, Letter, animal structures, [SDV]Life Sciences [q-bio], 2R hypothesis, Chordate, Mice, Transgenic, Genome, Evolution, Molecular, 03 medical and health sciences, Mice, 0302 clinical medicine, Chordata, Nonvertebrate, Branchiostoma floridae, Genetics, Gene family, Animals, Humans, [INFO]Computer Science [cs], Hox gene, Genetics (clinical), Phylogeny, 030304 developmental biology, Cephalochordate, 0303 health sciences, biology, Genes, Homeobox, biology.organism_classification, Vertebrates, 030217 neurology & neurosurgery |
| الوصف: | Cephalochordates, urochordates, and vertebrates evolved from a common ancestor over 520 million years ago. To improve our understanding of chordate evolution and the origin of vertebrates, we intensively searched for particular genes, gene families, and conserved noncoding elements in the sequenced genome of the cephalochordate Branchiostoma floridae, commonly called amphioxus or lancelets. Special attention was given to homeobox genes, opsin genes, genes involved in neural crest development, nuclear receptor genes, genes encoding components of the endocrine and immune systems, and conserved cis-regulatory enhancers. The amphioxus genome contains a basic set of chordate genes involved in development and cell signaling, including a fifteenth Hox gene. This set includes many genes that were co-opted in vertebrates for new roles in neural crest development and adaptive immunity. However, where amphioxus has a single gene, vertebrates often have two, three, or four paralogs derived from two whole-genome duplication events. In addition, several transcriptional enhancers are conserved between amphioxus and vertebrates—a very wide phylogenetic distance. In contrast, urochordate genomes have lost many genes, including a diversity of homeobox families and genes involved in steroid hormone function. The amphioxus genome also exhibits derived features, including duplications of opsins and genes proposed to function in innate immunity and endocrine systems. Our results indicate that the amphioxus genome is elemental to an understanding of the biology and evolution of nonchordate deuterostomes, invertebrate chordates, and vertebrates. |
| وصف الملف: | application/pdf; application/msword |
| اللغة: | English |
| تدمد: | 1088-9051 1549-5469 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27c0012fde459037ace2fba7069b0978 https://hdl.handle.net/11567/264206 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....27c0012fde459037ace2fba7069b0978 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10889051 15495469 |
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