Tissue Antioxidant Status and Lipid Peroxidation Are Related to Dietary Intake of n-3 Polyunsaturated Acids: A Rabbit Model
| العنوان: | Tissue Antioxidant Status and Lipid Peroxidation Are Related to Dietary Intake of n-3 Polyunsaturated Acids: A Rabbit Model |
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| المؤلفون: | Cesare Castellini, Gabriele Brecchia, Giulia Collodel, Simona Mattioli, Camille Oger, Anna Ida Fiaschi, Daniela Cerretani, Daria Noto, Elena Moretti, Claudio De Felice, Cinzia Signorini, Laura Menchetti, Elisa Cotozzolo, Lucia Micheli |
| المساهمون: | Università degli Studi di Perugia (UNIPG), Università degli Studi di Siena = University of Siena (UNISI), Università degli Studi di Milano [Milano] (UNIMI), University of Bologna, Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Azienda Ospedaliera Universitaria Senese |
| المصدر: | Antioxidants Volume 10 Issue 5 Antioxidants, Vol 10, Iss 681, p 681 (2021) Antioxidants, MDPI, 2021, 10 (5), pp.681. ⟨10.3390/antiox10050681⟩ |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, cellular antioxidants, Antioxidant, Physiology, medicine.medical_treatment, brain, Clinical Biochemistry, rabbit, RM1-950, vitamin E, testis, liver, Biochemistry, Article, Lipid peroxidation, 03 medical and health sciences, chemistry.chemical_compound, New Zealand white rabbit, isoprostanoids, medicine, Food science, Brain, Cellular antioxidants, Isoprostanoids, Liver, Polyunsaturated fatty acids, Rabbit, Testis, Vitamin E, Molecular Biology, 2. Zero hunger, chemistry.chemical_classification, medicine.diagnostic_test, biology, 0402 animal and dairy science, food and beverages, 04 agricultural and veterinary sciences, Cell Biology, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Fish oil, Malondialdehyde, biology.organism_classification, 040201 dairy & animal science, eye diseases, 3. Good health, brain, cellular antioxidants, isoprostanoids, liver, polyunsaturated fatty acids, rabbit, testis, vitamin E, 030104 developmental biology, chemistry, lipids (amino acids, peptides, and proteins), Therapeutics. Pharmacology, Lipid profile, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Polyunsaturated fatty acid, polyunsaturated fatty acids |
| الوصف: | Polyunsaturated fatty acid (PUFA) metabolism and tissue distribution is modulated by the oxidation of these molecules. This research aimed to investigate the implication of dietary n-3 PUFA supplementation (precursor and long-chain PUFA) on the PUFA profile and oxidative status of the liver, testis, and brain of adult rabbit bucks. Twenty New Zealand White rabbit bucks were divided into four experimental groups (n = 5 per group) and were fed different diets for 110 days: control (CNT), standard diet containing 50 mg/kg alpha-tocopheryl acetate (vitamin E) CNT+, standard diet + 200 mg/kg vitamin E FLAX, standard diet + 10% flaxseed + 200 mg/kg vitamin E or FISH, standard diet + 3.5% fish oil + 200 mg/kg vitamin E. Antioxidants (enzymatic and non-enzymatic), oxidative status (malondialdehyde and isoprostanoids), and n-3 and n-6 PUFAs of tissues were analysed. A chain mechanism of oxidant/antioxidant molecules, which largely depended on the particular PUFA composition, was delineated in the different organs. The liver showed an oxidant/antioxidant profile and lipid pathways widely modulated by PUFA and vitamin E administration on the other hand, the testis’ oxidative profile rather than its lipid profile seemed to be particularly affected, an outcome opposite to that of the brain (modulation operated by dietary PUFA). |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2076-3921 |
| DOI: | 10.3390/antiox10050681 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f668495341894103627121b42889e8 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....27f668495341894103627121b42889e8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20763921 |
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| DOI: | 10.3390/antiox10050681 |