A Comprehensive Expression Analysis of Mucins in Appendiceal Carcinoma in a Multicenter Study: MUC3 Is a Novel Prognostic Factor
| العنوان: | A Comprehensive Expression Analysis of Mucins in Appendiceal Carcinoma in a Multicenter Study: MUC3 Is a Novel Prognostic Factor |
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| المؤلفون: | Hideki Tsuji, Satoru Kawai, Toshiyuki Arai, Koutarou Hattori, Yukie Tashiro, Takashi Hiromatsu, Michihiko Narita, Shingo Kuze, Yasuhiro Kurumiya, Iwao Kitazono, Karine Rousseau, Hitoshi Kubota, Masahiko Osako, Eiji Sasaki, Norihiro Yuasa, Osamu Okochi, Masaki Sakamoto, Masahiko Fujino, Naomi Konishi, Hiroshi Hasagawa, Hiroaki Shibahara, Hiroshi Shirahama, Akinobu Kondo, Shinji Kondo, Michiyo Higashi, Yoshichika Okamoto, Suguru Yonezawa, Tatsuyoshi Yamamoto, Hideaki Suzuki, Surinder K. Batra, Seiya Yokoyama, Yu Sakai, Kazuhisa Shirai, Takehito Kato |
| المصدر: | PLoS ONE PLoS ONE, Vol 9, Iss 12, p e115613 (2014) |
| بيانات النشر: | Public Library of Science, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Male, Pathology, medicine.medical_specialty, Clinical Pathology, Colorectal cancer, Lymphovascular invasion, lcsh:Medicine, Pathology and Laboratory Medicine, Metastasis, Young Adult, Diagnostic Medicine, Pancreatic cancer, Gastrointestinal Tumors, Carcinoma, medicine, Medicine and Health Sciences, Mucinous carcinoma, Humans, lcsh:Science, Survival analysis, Aged, Aged, 80 and over, Multidisciplinary, business.industry, Cancer Risk Factors, Gene Expression Profiling, lcsh:R, Mucins, Cancer, Cancers and Neoplasms, Middle Aged, medicine.disease, Prognosis, Survival Analysis, 3. Good health, Oncology, Appendiceal Neoplasms, Multivariate Analysis, lcsh:Q, Female, business, Research Article |
| الوصف: | Background Mucins are implicated in survival in various cancers, but there have been no report addressed on survival in appendiceal carcinoma, an uncommon disease with different clinical and pathological features from those of other colon cancers. We aimed to investigate the clinical implications of expression of mucins in appendiceal carcinoma. Methods Expression profiles of MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC6, MUC16 and MUC17 in cancer tissue were examined by immunohistochemistry in 108 cases of surgically resected appendiceal carcinoma. Results The following relationships of mucins with clinicopathologic factors were identified: MUC1 with positive lymphatic invasion (p = 0.036); MUC2 with histological type (mucinous carcinoma, p |
| اللغة: | English |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2812abec133ea5975c8dcea8d65eb6b4 http://europepmc.org/articles/PMC4281150 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....2812abec133ea5975c8dcea8d65eb6b4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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