Early Changes in Quasispecies Repertoire in HIV-Infected Infants: Correlation with Disease Progression
| العنوان: | Early Changes in Quasispecies Repertoire in HIV-Infected Infants: Correlation with Disease Progression |
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| المؤلفون: | Gemma Rochford, Henry Pollack, William Borkowsky, Ivan Oransky, Keith Krasinski, Shaffiq Essajee |
| المصدر: | AIDS Research and Human Retroviruses. 16:1949-1957 |
| بيانات النشر: | Mary Ann Liebert Inc, 2000. |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | Immunology, HIV Infections, Heteroduplex Analysis, Viral quasispecies, Disease, HIV Envelope Protein gp120, Genes, env, Polymerase Chain Reaction, Virus, Evolution, Molecular, Virology, Immunopathology, Humans, Sida, biology, Infant, Newborn, Gene Products, env, Genetic Variation, Infant, biology.organism_classification, Peptide Fragments, Infectious Diseases, Viral evolution, Lentivirus, Disease Progression, HIV-1, Viral disease |
| الوصف: | The evolution of HIV-1 quasispecies in patients during the first year of life was investigated in 10 vertically infected infants, using heteroduplex analysis of the V3-V5 region of env. Four subjects, who showed little viral evolution during the period of the study, had rapid progression of disease and early loss of CD4(+) cells. The remaining six subjects, who were slow progressors, evolved new viral variants within 6 months, and in one case by 1 month of age. Of the four patients who were PCR positive at birth, one was infected with multiple HIV-1 variants. These results show that in HIV-infected children, multiple variants may initiate infection and early quasispecies diversification is associated with a favorable clinical outcome. |
| تدمد: | 1931-8405 0889-2229 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::281704760f48a9fe0130631773f87bd8 https://doi.org/10.1089/088922200750054675 |
| رقم الأكسشن: | edsair.doi.dedup.....281704760f48a9fe0130631773f87bd8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19318405 08892229 |
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