The association between RAPSN methylation in peripheral blood and breast cancer in the Chinese population
| العنوان: | The association between RAPSN methylation in peripheral blood and breast cancer in the Chinese population |
|---|---|
| المؤلفون: | Lixi Li, Fei Ma, Wenjie Zhou, Wanjian Gu, Rongxi Yang, Shuifang Lei, Xiaoqin Yang, Tian Xu, Qiming Yin |
| المصدر: | Journal of Human Genetics. 66:1069-1078 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Fatty Acid Desaturases, 0301 basic medicine, Receptor, ErbB-2, Physiology, Breast Neoplasms, 030105 genetics & heredity, Logistic regression, Epigenesis, Genetic, 03 medical and health sciences, Breast cancer, Biomarkers, Tumor, Genetics, Humans, Medicine, Genetic Predisposition to Disease, Genetics (clinical), Aged, business.industry, Methylation, Odds ratio, DNA Methylation, Middle Aged, medicine.disease, Peripheral blood, RAPSN, 030104 developmental biology, CpG site, DNA methylation, CpG Islands, Female, business |
| الوصف: | DNA methylation in peripheral blood is associated with breast cancer (BC) but has mainly been studied in Caucasian populations. We investigated the association between blood-based methylation of receptor-associated protein of the synapse (RAPSN) and BC in Chinese population. The methylation levels of 12 RAPSN CpG sites were quantitatively evaluated by mass spectrometry in two case-control studies with 283 sporadic BC cases and 331 controls totally. The association was analyzed by logistic regression adjusted for covariants. The RAPSN methylation levels in patients with variant clinical characteristics were investigated by non-parametric tests. We found a significant association between BC and altered RAPSN methylation in blood in women at premenopausal and perimenopausal (age < 50 years old), but not in the elder women. This was approved by two independent case-control studies as well as by combining the subjects of the two studies (taken all subjects together, age < 50 years old, per 5% of methylation, odds ratio (OR) range from 1.17 to 1.30 for two CpG sites; OR = 0.75 for one CpG site; all p values < 0.02). This age-related RAPSN methylation was further modified by human epidermal growth factor receptor 2 (HER2) status (age < 50 years old, HER2 negative, per 5% of methylation, OR range from 1.27 to 1.48 for two CpG sites; OR = 0.76 for one CpG site; all p values < 0.02). We elucidated an association between BC and blood-based RAPSN methylation influenced by age and the status of HER2 in Chinese population. |
| تدمد: | 1435-232X 1434-5161 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2824088d1ceebc90cc7eb78ce3f5652c https://doi.org/10.1038/s10038-021-00933-x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....2824088d1ceebc90cc7eb78ce3f5652c |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 1435232X 14345161 |
|---|