Synthesis and Evaluation of Bingel-Hirsch Multiadducts of Paramagnetic Gadofullerene as Potential Magnetic Resonance Imaging Contrast Agents
| العنوان: | Synthesis and Evaluation of Bingel-Hirsch Multiadducts of Paramagnetic Gadofullerene as Potential Magnetic Resonance Imaging Contrast Agents |
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| المؤلفون: | Hong Zhao, Rui He, Yanhua Jiao, Xuxia Wang, Hui Yuan, Jinquan Dong, Gengmei Xing, Shukuan Wang, Hao Lei |
| المصدر: | Journal of Nanoscience and Nanotechnology. 13:1549-1554 |
| بيانات النشر: | American Scientific Publishers, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Hydride, Gadolinium, Biomedical Engineering, Analytical chemistry, chemistry.chemical_element, Bioengineering, General Chemistry, Buffer solution, Condensed Matter Physics, Mass spectrometry, Medicinal chemistry, chemistry.chemical_compound, Matrix-assisted laser desorption/ionization, Malonate, chemistry, Metallofullerene, General Materials Science, Bingel reaction |
| الوصف: | Water-soluble malonate multiadducts of paramagnetic gadolinium endohedral metallofullerene, Gd@C-82[C(COOH)(2)](6) and Gd@C-82[C(COOH)(2)](8), were synthesized by Bingel-Hirsch reaction. Gd@C-82 was firstly reacted with diethyl bromomalonate in the presence of alkali metal hydride to produce malonic ester multiadducted derivatives, Gd@C-82[C(OOCH2CH3)(2)](x) (x = 3-8), by Bingel reaction. They were isolated and purified to obtain Gd@C-82[C(COOCH2CH3)(2)](6) and Gd@C-82[C(COOCH2CH3)(2)](8) by silica-gel column chromatography with a gradient elution method, which were subsequently hydrolyzed to yield water-soluble Gd@C-82[C(COOH)(2)](6) and Gd@C-82[C(COOH)(2)](8) by Hirsch reaction. The structures of the derivatives were characterized by Fourier transform infrared spectrometry and matrix assisted laser desorption ionization time-of-flight mass spectrometry. The longitudinal relaxivities of Gd@C-82[C(COOH)(2)](8) and Gd@C-82[C(COOH)(2)](6), in buffer solution, were found to be 18.20 and 11.08 mM(-1) s(-1) concentration range between 0.001-0.025 mM Gd, and to be 12.71 and 6.73 mM(-1) s(-1) between 0.050-0.200 mM Gd, respectively. The results showed that the measured relaxivities for malonate derivatives of Gd@C-82 were dependent on the concentration of these solutions and the number of hydrophilic carboxyl groups appended on the surface of the Gd@C-82 cage. |
| تدمد: | 1533-4899 1533-4880 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28603a16686a8d2be1adf23e959ab2d0 https://doi.org/10.1166/jnn.2013.5993 |
| رقم الأكسشن: | edsair.doi.dedup.....28603a16686a8d2be1adf23e959ab2d0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15334899 15334880 |
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