Fecal Microbiota Transplant for Recurrent Clostridium difficile Infection in Pediatric Inflammatory Bowel Disease
| العنوان: | Fecal Microbiota Transplant for Recurrent Clostridium difficile Infection in Pediatric Inflammatory Bowel Disease |
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| المؤلفون: | Robert Hirten, Marla Dubinsky, Elizabeth A. Spencer, Stanley Cho, Ari Grinspan |
| المصدر: | Journal of Pediatric Gastroenterology & Nutrition. 68:343-347 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Adolescent, Severity of Illness Index, digestive system, Gastroenterology, Inflammatory bowel disease, 03 medical and health sciences, 0302 clinical medicine, Recurrence, Vancomycin, 030225 pediatrics, Internal medicine, Severity of illness, medicine, Humans, In patient, Longitudinal Studies, Child, Retrospective Studies, business.industry, Retrospective cohort study, Fecal bacteriotherapy, Fecal Microbiota Transplantation, Clostridium difficile, Inflammatory Bowel Diseases, medicine.disease, digestive system diseases, Anti-Bacterial Agents, Pediatrics, Perinatology and Child Health, Clostridium Infections, Female, 030211 gastroenterology & hepatology, business |
| الوصف: | Recurrent Clostridium difficile infection (RCDI) increases morbidity and mortality in patients with inflammatory bowel disease (IBD). Fecal microbiota transplant (FMT) is known to be very effective for RCDI in non-IBD patients with cure rates up to 91%. The same success rates of FMT have not been reported in patients with IBD with RCDI, and the data in pediatrics are limited. We aimed to determine the effectiveness of FMT for RCDI in established pediatric patients with IBD.We performed a retrospective chart review of pediatric patients with IBD and RCDI (≥3 episodes) who underwent FMT via colonoscopy at a tertiary care IBD center. The primary outcome was the rate of RCDI within 60 days post-FMT. The secondary outcomes were recurrence rate by 6 months, rate of colectomy, and time to recurrence.Of the 8 eligible patients, 6 had ulcerative colitis, 1 had IBD-unspecified, and 1 had Crohn disease. Median (interquartile range) age was 13 (11-14) years. All patients were on vancomycin at FMT. Two patients (25%) had RCDI by 60 days post-FMT and another 3 patients had RCDI between 60 days and 6 months. The median time to recurrence was 101 (40-139) days. Two patients (25%) who developed recurrence went to colectomy after FMT.With a cure rate of 75% at 60 days, FMT administered for the treatment of RCDI may be an effective treatment option in pediatric IBD. However, there appears to be a significant rate of late recurrence of C difficile infection after 60 days in these patients. |
| تدمد: | 1536-4801 0277-2116 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::287f0963e19879a7903b6244005cfce5 https://doi.org/10.1097/mpg.0000000000002172 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....287f0963e19879a7903b6244005cfce5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15364801 02772116 |
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