Microsomal triglyceride transfer protein polymorphisms and lipoprotein levels in type 2 diabetes
| العنوان: | Microsomal triglyceride transfer protein polymorphisms and lipoprotein levels in type 2 diabetes |
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| المؤلفون: | Catherine M. Phillips, Daphne Owens, K. Mullan, G. H. Tomkin |
| المصدر: | QJM. 97:211-218 |
| بيانات النشر: | Oxford University Press (OUP), 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Male, Apolipoprotein E, medicine.medical_specialty, Very low-density lipoprotein, Apolipoprotein B, Lipoproteins, VLDL, Microsomal triglyceride transfer protein, chemistry.chemical_compound, Internal medicine, Chylomicrons, Humans, Medicine, Aged, Polymorphism, Genetic, biology, medicine.diagnostic_test, business.industry, Cholesterol, General Medicine, Middle Aged, Endocrinology, Diabetes Mellitus, Type 2, chemistry, biology.protein, Female, lipids (amino acids, peptides, and proteins), Carrier Proteins, business, Lipid profile, Chylomicron, Lipoprotein |
| الوصف: | Summary Background: Microsomal triglyceride transfer protein (MTP) regulates the assembly of chylomicrons in the intestine and very-low-density lipoprotein (VLDL) in the liver. Common polymorphisms have been described that do not affect lipoproteins in non-diabetic subjects. Their effect in diabetes has not been described in a Caucasian population. Aim: To investigate the association of these three common polymorphisms with lipoproteins in type 2 diabetes. Methods: Eighty-two patients consumed a high-fat test meal. Chylomicron and VLDL apoB48, apoB100, cholesterol, triglycerides and phospholipids were measured fasting, and at 4 and 6 h postprandially. MTP genotyping was performed by PCR-RFLP. Results: Thirty-three subjects were heterozygous for the � 493 G/T substitution. These patients had significantly lower LDL cholesterol (3.0 � 0.2 vs. 3.5 � 0.1 mmol/l, p < 0.02). In the postprandial period, they had higher levels of apoB48 in the VLDL fraction (4 h, 7.0 � 1.4 vs. 2.9 � 0.4mg/ml plasma, p < 0.002; 6 h, 6.4 � 1.0 vs. 3.5 � 0.5mg/ml plasma, p < 0.05). In the VLDL fraction there was significantly less cholesterol at 4 and 6 h (p < 0.05). The � 400 A/T substitution gave very similar lipoprotein results, but there was significant linkage dysequilibrium between the two polymorphisms. No association was found between the � 164 T/C polymorphism and either plasma lipids or the postprandial lipid profile. ApoE genotype was also examined, but did not influence the above results. Discussion: The common � 493 G/T MTP polymorphism is associated with changes in VLDL and LDL in Type 2 diabetic patients. The importance of the changes in apoB48-containing small particles requires further investigation. The significantly lower LDL cholesterol suggests that this polymorphism may confer protection against atherosclerosis in type 2 diabetes. |
| تدمد: | 1460-2393 1460-2725 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28cc9388def11d93f9b74460e62fc1d1 https://doi.org/10.1093/qjmed/hch040 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....28cc9388def11d93f9b74460e62fc1d1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14602393 14602725 |
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