The role of peripheral immune cells in the CNS in steady state and disease
| العنوان: | The role of peripheral immune cells in the CNS in steady state and disease |
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| المؤلفون: | Josef Priller, Marco Prinz |
| المصدر: | Nature reviews / Neuroscience 20(2), 136-144 (2017). doi:10.1038/nn.4475 |
| بيانات النشر: | Springer Science and Business Media LLC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Central Nervous System, 0301 basic medicine, physiopathology [Central Nervous System], Neutrophils, T-Lymphocytes, physiopathology [Central Nervous System Diseases], Ischemia, Context (language use), Disease, immunology [Blood-Brain Barrier], Monocytes, immunology [T-Lymphocytes], immunology [Monocytes], 03 medical and health sciences, Immune system, Central Nervous System Diseases, ddc:570, medicine, Animals, Humans, physiopathology [Blood-Brain Barrier], immunology [Central Nervous System Diseases], immunology [Neutrophils], Innate immune system, immunology [Central Nervous System], business.industry, General Neuroscience, Multiple sclerosis, Innate lymphoid cell, medicine.disease, 030104 developmental biology, Blood-Brain Barrier, Immunology, business, Neuroscience, Homeostasis |
| الوصف: | The CNS is protected by the immune system, including cells that reside directly within the CNS and help to ensure proper neural function, as well as cells that traffic into the CNS with disease. The CNS-resident immune system is comprised mainly of innate immune cells and operates under homeostatic conditions. These myeloid cells in the CNS parenchyma and at CNS-periphery interfaces are highly specialized but also extremely plastic cells that immediately react to any changes in CNS homeostasis and become reactive in the context of neurodegenerative disorders such as Alzheimer's disease or Parkinson's disease. However, when the blood-brain barrier is impaired during CNS diseases such as multiple sclerosis or altered with cerebral ischemia, peripheral adaptive and innate immune cells, including monocytes, neutrophils, T cells and B cells, can enter the CNS, where they execute distinct cell-mediated effects. On the basis of these observations, we assess strategies for targeting peripheral immune cells to reduce CNS disease burden. |
| تدمد: | 1546-1726 1097-6256 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2923ce1b88d3b5b3d5abfec14889527c https://doi.org/10.1038/nn.4475 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....2923ce1b88d3b5b3d5abfec14889527c |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15461726 10976256 |
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