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Improving medication adherence with adjuvant aromatase inhibitor in women with breast cancer: A randomised controlled trial to evaluate the effect of short message service (SMS) reminder

التفاصيل البيبلوغرافية
العنوان: Improving medication adherence with adjuvant aromatase inhibitor in women with breast cancer: A randomised controlled trial to evaluate the effect of short message service (SMS) reminder
المؤلفون: Bee Choo Tai, Soo-Chin Lee, Andrea Li Ann Wong, Siew Eng Lim, Patrick Wong, Li En Yvonne Ang, Wan Qin Chong, Eng Hooi Tan, Jingshan Ho, Chuan Chien Tan, Sing Huang Tan
المصدر: Breast, Vol 53, Iss, Pp 77-84 (2020)
The Breast : official journal of the European Society of Mastology
بيانات النشر: Elsevier, 2020.
سنة النشر: 2020
مصطلحات موضوعية: Adult, medicine.medical_specialty, medicine.drug_class, medicine.medical_treatment, Estrone, Breast Neoplasms, Logistic regression, lcsh:RC254-282, law.invention, Medication Adherence, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Breast cancer, Randomized controlled trial, law, Internal medicine, Medicine, Humans, 030212 general & internal medicine, Androstenedione, Prospective Studies, Aged, Aged, 80 and over, Randomised controlled trial, Text Messaging, Aromatase inhibitor, business.industry, Aromatase Inhibitors, General Medicine, Middle Aged, SMS reminder, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Logistic Models, chemistry, Chemotherapy, Adjuvant, Adherence, 030220 oncology & carcinogenesis, Surgery, Original Article, Female, Self Report, business, Adjuvant, Hormone
الوصف: Background Medication adherence is crucial for improving clinical outcomes in the treatment of patients. We evaluate the effect of short message service (SMS) reminder on medication adherence and serum hormones in patients with breast cancer on aromatase inhibitors. Methods An open-label, multi-centre, prospective randomised controlled trial of SMS versus Standard Care was conducted. Medication adherence was assessed via self-report using the Simplified Medication Adherence Questionnaire at baseline, 6 month, and 1 year. Androstenedione, estradiol, and estrone were measured at baseline and 1 year. The χ2 test and mixed effects logistic regression was performed to compare medication adherence between groups. Difference in androstenedione and estrone levels were assessed using analysis of covariance, whereas χ2 test and logistic regression was used for estradiol. Analysis was based on intention-to-treat. Results A total of 244 patients were randomised to receive weekly SMS reminder (n = 123) or Standard Care (n = 121) between May 2015 and December 2018. The odds of adherence was higher at 6-month in SMS (OR = 1.78, 95% CI 1.04–3.05, p = 0.034), and not significantly different at 1-year (OR = 1.15, 95% CI: 0.67–1.96 p = 0.617). Mixed effects logistic regression analysis showed higher odds of adherence in SMS over the 1-year period (OR = 2.35, 95% CI: 1.01–5.49, p = 0.048). There was no difference in serum hormone levels between groups. Conclusion SMS reminder improved medication adherence in the short-term but had no effect on serum hormones levels in the longer term. Future studies could investigate the use of tailored SMS intervention according to patient preference to improve its sustainability.
Highlights • Patients on aromatase inhibitors were randomised to SMS reminder or Standard Care. • SMS reminder improved medication adherence in the short-term. • There was no effect on serum hormones levels in the longer term.
اللغة: English
تدمد: 1532-3080
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2924c0d3432f2529899c4b9d40fe862b
http://www.sciencedirect.com/science/article/pii/S0960977620301429
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....2924c0d3432f2529899c4b9d40fe862b
قاعدة البيانات: OpenAIRE
الوصف
تدمد:15323080