Clinicopathological differences in radiation-induced organizing hematomas of the brain based on type of radiation treatment and primary lesions
| العنوان: | Clinicopathological differences in radiation-induced organizing hematomas of the brain based on type of radiation treatment and primary lesions |
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| المؤلفون: | Myung Sun Kim, Yoon Jin Cha, Jong-Hee Chang, Mina Park, Se Hoon Kim |
| المصدر: | Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine, Vol 56, Iss 1, Pp 16-21 (2022) |
| بيانات النشر: | The Korean Society of Pathologists/The Korean Society for Cytopathology, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Gamma-knife surgery, Histology, business.industry, medicine.medical_treatment, Radiation induced, Arteriovenous malformation, medicine.disease, Pathology and Forensic Medicine, Metastasis, Lesion, Hemangioma, Radiation therapy, Radiation-induced organizing hematoma, Cavernous hemangioma, Gamma knife surgery, Glioma, Latency, Pathology, medicine, RB1-214, Original Article, medicine.symptom, business, Nuclear medicine |
| الوصف: | Background: Radiation-induced organizing hematoma (RIOH) is a sporadic form of cavernous hemangioma (CH) that occurs after cerebral radiation. RIOH lesions are distinct histologically from de novo CH; however, detailed research on this subject is lacking. In the present study, the clinical and histological features of RIOHs were evaluated based on causative lesions. Methods: The present study included 37 RIOHs confirmed by surgical excision from January 2009, to May 2020, in Yonsei Severance Hospital. All cases were divided into subgroups based on type of radiation treatment (gamma knife surgery [GKS], n = 24 vs. conventional radiation therapy [RT], n = 13) and pathology of the original lesion (arteriovenous malformation, n = 14; glioma, n = 12; metastasis, n = 4; other tumors, n = 7). The clinicopathological results were compared between the groups. Results: Clinical data of multiplicity, latency, and size and wall thickness of the original tumors and RIOHs were analyzed. The GKS group showed shorter latency (5.85 ± 4.06 years vs. 11.15 ± 8.27 years, p = .046) and thicker tumor wall (693.7 ± 565.7 μm vs. 406.9 ± 519.7 μm, p = .049) than the conventional RT group. Significant difference was not found based on original pathology. Conclusions: RIOH is more likely to occur earlier with thick tumor wall in subjects who underwent GKS than in patients who underwent conventional RT. These results indicate the clinical course of RIOH differs based on type of treatment and might help determine the duration of follow-up. |
| اللغة: | English |
| تدمد: | 2383-7845 2383-7837 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::293b0e1fe524cc76196a0d3d1319ecd9 http://europepmc.org/articles/PMC8743802 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....293b0e1fe524cc76196a0d3d1319ecd9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23837845 23837837 |
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