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// Jin-Peng Wang 1, 2, 3 , Yan-Yan Tang 1, 2 , Chun-Mei Fan 2 , Can Guo 2 , Yan-Hong Zhou 2 , Zheng Li 2 , Xiao-Ling Li 2 , Yong Li 2, 4 , Gui-Yuan Li 1, 2, 3 , Wei Xiong 1, 2, 3 , Zhao-Yang Zeng 1, 2, 3 and Fang Xiong 1 1 The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, China 2 The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China 3 Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China 4 Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA Correspondence to: Fang Xiong, email: xiongf@csu.edu.cn Zhao-Yang Zeng, email: zengzhaoyang@csu.edu.cn Keywords: exosome; non-coding RNA; tumor microenvironment; tumor metastasis Received: July 10, 2017 Accepted: October 28, 2017 Published: December 21, 2017 ABSTRACT An increasing number of studies has confirmed that many cells can secrete vesicles or exosomes in eukaryotes, which contain important nucleic acids, proteins and lipids and play important roles in cell communication and tumor metastasis. This paper summarizes the comprehensive function of exosomal non-coding RNAs. Although some studies have shown that exosomes mediate tumor signal transduction, the functional mechanism of the tumor metastasis remains to be elucidated. In this paper, we reviewed the role of exosomal non-coding RNAs in mediating cancer metastasis in the tumor microenvironment to provide new ideas for the study of tumor pathophysiology. |
