CNS function and dysfunction during exposure to hyperbaric oxygen in operational and clinical settings
| العنوان: | CNS function and dysfunction during exposure to hyperbaric oxygen in operational and clinical settings |
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| المؤلفون: | Geoffrey E. Ciarlone, Jay B. Dean, Christopher M. Hinojo, Nicole M. Stavitzski |
| المصدر: | Redox Biology, Vol 27, Iss, Pp-(2019) Redox Biology |
| بيانات النشر: | Elsevier, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Central Nervous System, Clinical Biochemistry, CO2, carbon dioxide, E2, estradiol, Biochemistry, FIO2, fractional concentration of inspired oxygen, 0302 clinical medicine, USN, United States Navy, Seizure mitigation, Seizure genesis, Reactive oxygen and nitrogen species, CN, cranial nerve, PIO2, partial pressure of inspired oxygen, Oxygen toxicity, lcsh:QH301-705.5, Hyperoxia, AED, anti-epileptic drugs, ATA, atmospheres absolute pressure, Hyperbaric Oxygenation, lcsh:R5-920, Respiration, PCO2, partial pressure of carbon dioxide, Cns function, OxIP, oxygen-induced potentiation, NMDA, N-methyl-d-aspartate, DISSUB, disabled submarine, medicine.anatomical_structure, PB, barometric pressure, Neurological, Breathing, NADPH, Nicotinamide adenine dinucleotide phosphate, medicine.symptom, CBF, cerebral blood flow, lcsh:Medicine (General), Brainstem, Oxidation-Reduction, medicine.medical_specialty, fsw, feet of sea water, CNS-OT, central nervous system oxygen toxicity, Central nervous system, CNS, central nervous system, Neuroprotection, VENTID-C, Vison-Ears-Nausea-Twitching/Tingling-Irritability-Dizziness-Convulsions, RONS, reactive oxygen and nitrogen species, 03 medical and health sciences, Hyperbaric oxygen, NTS, nucleus tractus solitarius, cSC, caudal Solitary Complex, medicine, Animals, Humans, HBOT, hyperbaric oxygen therapy, O2, oxygen, Intensive care medicine, PO2, partial pressure of oxygen, HBO2, hyperbaric oxygen, RN, Royal Navy, Glu, glutamate, business.industry, Organic Chemistry, DCS, decompression sickness, mm Hg, millimeters of Mercury, Cardiorespiratory fitness, GABA, Gamma-Aminobutyric Acid, medicine.disease, LOC, loss of consciousness, Oxygen, 030104 developmental biology, lcsh:Biology (General), HBO2-PC, hyperbaric oxygen preconditioning, business, N2, nitrogen, S/Sx, signs and symptoms, DHE, dihydroethidium, 030217 neurology & neurosurgery, CNS oxygen toxicity |
| الوصف: | Hyperbaric oxygen (HBO2) is breathed during hyperbaric oxygen therapy and during certain undersea pursuits in diving and submarine operations. What limits exposure to HBO2 in these situations is the acute onset of central nervous system oxygen toxicity (CNS-OT) following a latent period of safe oxygen breathing. CNS-OT presents as various non-convulsive signs and symptoms, many of which appear to be of brainstem origin involving cranial nerve nuclei and autonomic and cardiorespiratory centers, which ultimately spread to higher cortical centers and terminate as generalized tonic-clonic seizures. The initial safe latent period makes the use of HBO2 practical in hyperbaric and undersea medicine; however, the latent period is highly variable between individuals and within the same individual on different days, making it difficult to predict onset of toxic indications. Consequently, currently accepted guidelines for safe HBO2 exposure are highly conservative. This review examines the disorder of CNS-OT and summarizes current ideas on its underlying pathophysiology, including specific areas of the CNS and fundamental neural and redox signaling mechanisms that are thought to be involved in seizure genesis and propagation. In addition, conditions that accelerate the onset of seizures are discussed, as are current mitigation strategies under investigation for neuroprotection against redox stress while breathing HBO2 that extend the latent period, thus enabling safer and longer exposures for diving and medical therapies. Keywords: CNS oxygen toxicity, Hyperoxia, Reactive oxygen and nitrogen species, Brainstem, Seizure genesis, Seizure mitigation |
| اللغة: | English |
| تدمد: | 2213-2317 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29cde87d7e2e99057714ba6c9abd0dab http://www.sciencedirect.com/science/article/pii/S2213231719301181 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....29cde87d7e2e99057714ba6c9abd0dab |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22132317 |
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