Mitochondria-Targeting Polymer Micelle of Dichloroacetate Induced Pyroptosis to Enhance Osteosarcoma Immunotherapy
| العنوان: | Mitochondria-Targeting Polymer Micelle of Dichloroacetate Induced Pyroptosis to Enhance Osteosarcoma Immunotherapy |
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| المؤلفون: | Jiakang Jin, Pengcheng Yuan, Wei Yu, Jinti Lin, Ankai Xu, Xiaodan Xu, Jianan Lou, Tao Yu, Chao Qian, Bing Liu, Jiashi Song, Lijun Li, Ying Piao, Tao Xie, Youqing Shen, Huimin Tao, Jianbin Tang |
| المصدر: | ACS Nano. 16:10327-10340 |
| بيانات النشر: | American Chemical Society (ACS), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Osteosarcoma, Polymers, Cell Line, Tumor, Pyroptosis, Tumor Microenvironment, General Engineering, Humans, General Physics and Astronomy, Bone Neoplasms, General Materials Science, Immunotherapy, Micelles, Mitochondria |
| الوصف: | Pyroptosis has been reported to improve the immunosuppressive tumor microenvironment and may be a strategy to enhance osteosarcoma treatment. The extent to which modulation of mitochondria could induce tumor pyroptosis to enhance immunotherapy has not been characterized. We synthesized a mitochondria-targeting polymer micelle (OPDEA-PDCA), in which poly[2-( |
| تدمد: | 1936-086X 1936-0851 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e8f6448a790e846a42dd0d65e586e8 https://doi.org/10.1021/acsnano.2c00192 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....29e8f6448a790e846a42dd0d65e586e8 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 1936086X 19360851 |
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