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Hepatitis B core related antigen in relation to intrahepatic and circulating viral markers, before and after combination therapy

التفاصيل البيبلوغرافية
العنوان: Hepatitis B core related antigen in relation to intrahepatic and circulating viral markers, before and after combination therapy
المؤلفون: Ed Bakker, Robin Erken, Henk W. Reesink, S.B. Willemse, Neeltje A. Kootstra, Hans L. Zaaijer, Bart B. Takkenberg
المصدر: Annals of Hepatology, Vol 26, Iss, Pp 100540-(2021)
بيانات النشر: Elsevier BV, 2021.
سنة النشر: 2021
مصطلحات موضوعية: Adult, Male, Hepatitis B virus, medicine.medical_specialty, HBsAg, Combination therapy, Specialties of internal medicine, Adefovir, HBV pgRNA, medicine.disease_cause, Antiviral Agents, Gastroenterology, Viral markers, Hepatitis B, Chronic, Pegylated interferon, Internal medicine, medicine, Humans, Prospective Studies, Hepatology, business.industry, virus diseases, General Medicine, cccDNA, Viral Load, Hepatitis B, medicine.disease, Hepatitis B Core Antigens, digestive system diseases, RC581-951, Liver, DNA, Viral, Female, HBcrAg, business, Viral load, Biomarkers, Follow-Up Studies, medicine.drug
الوصف: Introduction and Objectives: Covalently closed circular (ccc)DNA acts as a viral reservoir in the liver of patients with a chronic hepatitis B (CHB) infection and can only be quantified in liver biopsies. Hepatitis B core-related antigen (HBcrAg) levels in plasma/serum have been proposed to reflect intrahepatic cccDNA-levels and may therefore monitor treatment efficacy. This study aimed to validate the relationship between HBcrAg and other intrahepatic and circulating viral markers in CHB patients with high viral load, before and after combination treatment. Materials and methods: Plasma/serum levels of HBcrAg, HBsAg, HBV-DNA, and HBV pregenomic RNA (HBV-pgRNA), and intrahepatic cccDNA and HBV-DNA levels and fibrosis scores were measured in 89 CHB patients with HBV-DNA levels of >100,000 copies/mL (17,182 IU/mL). Measurements were done before and after a 48-week treatment with pegylated interferon alfa-2a and adefovir in a prospective study (ISRCTN77073364). Results: Baseline HBcrAg-values correlated strongly with intrahepatic cccDNA (ρ 0.77, p
تدمد: 1665-2681
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29eb8e167acfdd8671dc87d4d5a8ab16
https://doi.org/10.1016/j.aohep.2021.100540
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....29eb8e167acfdd8671dc87d4d5a8ab16
قاعدة البيانات: OpenAIRE
الوصف
تدمد:16652681