Advanced PLGA hybrid scaffold with a bioactive PDRN/BMP2 nanocomplex for angiogenesis and bone regeneration using human fetal MSCs
| العنوان: | Advanced PLGA hybrid scaffold with a bioactive PDRN/BMP2 nanocomplex for angiogenesis and bone regeneration using human fetal MSCs |
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| المؤلفون: | Da-Seul Kim, Jun-Kyu Lee, Jun Hyuk Kim, Jaemin Lee, Dong Seon Kim, Sanghyun An, Sung-Bin Park, Tae-Hyung Kim, Jong Seop Rim, Soonchul Lee, Dong Keun Han |
| المصدر: | Science Advances |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Multidisciplinary, Applied Sciences and Engineering, Materials Science, SciAdv r-articles, Biomedicine and Life Sciences, Research Article |
| الوصف: | Description Nanocomplex immobilized scaffold effects on anti-inflammation, antibacterial activity, angiogenesis, and bone regeneration. Biodegradable polymers have been used with various systems for tissue engineering. Among them, poly(lactic-co-glycolic) acid (PLGA) has been widely used as a biomaterial for bone regeneration because of its great biocompatibility and biodegradability properties. However, there remain substantial cruxes that the by-products of PLGA result in an acidic environment at the implanting site, and the polymer has a weak mechanical property. In our previous study, magnesium hydroxide (MH) and bone extracellular matrix are combined with a PLGA scaffold (PME) to improve anti-inflammation and mechanical properties and osteoconductivity. In the present study, the development of a bioactive nanocomplex (NC) formed along with polydeoxyribonucleotide and bone morphogenetic protein 2 (BMP2) provides synergistic abilities in angiogenesis and bone regeneration. This PME hybrid scaffold immobilized with NC (PME/NC) achieves outstanding performance in anti-inflammation, angiogenesis, and osteogenesis. Such an advanced PME/NC scaffold suggests an integrated bone graft substitute for bone regeneration. |
| تدمد: | 2375-2548 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29f3cc2406c91b708ef5ceecced9a26b https://pubmed.ncbi.nlm.nih.gov/34878837 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....29f3cc2406c91b708ef5ceecced9a26b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23752548 |
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