Introduction Contraception is regarded as an important preventive measure of unintended pregnancies and sexually transmitted diseases, including human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS), among youths. This study aimed to assess the knowledge, attitude, and practice of contraception among female undergraduates in Dodoma, Tanzania. Methodology A cross-sectional study was conducted among 347 female undergraduates of St John’s University, Dodoma. Descriptive statistics were used for data analysis. Statistical analysis was done using Epi-Info version 7.2.2.6 (Centers for Disease Control and Prevention, Atlanta, Georgia. A p-value of less than 0.05 was considered statistically significant. Results The mean (±SD) age of participants was 27.4 (± 5.7). The majority (96%) of the participants were aware of contraception. Awareness of contraception was significantly associated with the age (p
