Expamers: a new technology to control T cell activation
| العنوان: | Expamers: a new technology to control T cell activation |
|---|---|
| المؤلفون: | Stefan Dreher, David G. Kugler, Mateusz Pawel Poltorak, Bojana Borjan, Christian Stemberger, Lothar Germeroth, Michaela Wagner, Martin Turk, Juergen M. Plitzko, Dirk H. Busch, Claudia Tschulik, Seamus Ragan, Manuel Effenberger, Vlad Cletiu, Patricia Graef, Thomas Schmidt, Simon P. Fraessle |
| المصدر: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Dependent manner, Computer science, medicine.medical_treatment, T cell, T-Lymphocytes, Cell, lcsh:Medicine, Cancer immunotherapy, Lymphocyte Activation, Immunotherapy, Adoptive, Article, 03 medical and health sciences, Mice, 0302 clinical medicine, Antigen, medicine, Animals, Humans, lcsh:Science, Cell Proliferation, Multidisciplinary, Cell growth, Gene Expression Profiling, lcsh:R, Immunotherapy, Cell biology, 030104 developmental biology, medicine.anatomical_structure, lcsh:Q, Indicators and Reagents, 030215 immunology |
| الوصف: | T cell activation is a cornerstone in manufacturing of T cell-based therapies, and precise control over T cell activation is important in the development of the next generation T-cell based therapeutics. This need cannot be fulfilled by currently available methods for T cell stimulation, in particular not in a time dependent manner. Here, we describe a modular activation reagent called Expamers, which addresses these limitations. Expamers are versatile stimuli that are intended for research and clinical use. They are readily soluble and can be rapidly bound and removed from the cell surface, allowing nearly instantaneous initiation and termination of activation signal, respectively. Hence, Expamers enable precise regulation of T cell stimulation duration and provide promise of control over T cell profiles in future products. Expamers can be easily adopted to different T cell production formats and have the potential to increase efficacy of T cell immunotherapeutics. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a4843928088aa78172b9e995707c3be https://hdl.handle.net/21.11116/0000-0007-DF9E-D21.11116/0000-0007-DFA0-921.11116/0000-0007-DFA1-821.11116/0000-0007-DFA2-7 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....2a4843928088aa78172b9e995707c3be |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |