Hypermutation in mantle cell lymphoma does not indicate a clinical or biological subentity
| العنوان: | Hypermutation in mantle cell lymphoma does not indicate a clinical or biological subentity |
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| المؤلفون: | Konnie M. Hebeda, Martin-Leo Hansmann, Johan H. J. M. van Krieken, Ed Schuuring, Margit Schraders, Sabine Oeschger, Patricia J. T. A. Groenen, Philip M. Kluin |
| المساهمون: | Damage and Repair in Cancer Development and Cancer Treatment (DARE), Stem Cell Aging Leukemia and Lymphoma (SALL), Targeted Gynaecologic Oncology (TARGON) |
| المصدر: | Modern Pathology, 22, 416-25 Modern Pathology, 22, 3, pp. 416-25 Modern Pathology, 22(3), 416-425. Nature Publishing Group |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Male, Pathology, Genetics and epigenetic pathways of disease [NCMLS 6], Chronic lymphocytic leukemia, Cell, Lymphoma, Mantle-Cell, V-H GENES, Polymerase Chain Reaction, COMPARATIVE GENOMIC HYBRIDIZATION, Aged, 80 and over, biology, Middle Aged, Phenotype, Immunohistochemistry, somatic hypermutation, Blotting, Southern, medicine.anatomical_structure, B-CELLS, Female, Antibody, Adult, medicine.medical_specialty, Age-related aspects of cancer [ONCOL 2], Molecular Sequence Data, mantle cell lymphoma, Somatic hypermutation, Pathology and Forensic Medicine, Immunoglobulin kappa-Chains, Immunoglobulin lambda-Chains, Translational research [ONCOL 3], POOR-PROGNOSIS, medicine, Humans, Aged, Hereditary cancer and cancer-related syndromes [ONCOL 1], Base Sequence, CHRONIC LYMPHOCYTIC-LEUKEMIA, SOMATIC MUTATIONS, IN-SITU HYBRIDIZATION, medicine.disease, Lymphoma, V(H) gene usage, RHEUMATOID-ARTHRITIS, SOUTHERN BLOT ANALYSIS, Immunology, IMMUNOGLOBULIN, biology.protein, Mantle cell lymphoma, Somatic Hypermutation, Immunoglobulin, Comparative genomic hybridization |
| الوصف: | Contains fulltext : 80422.pdf (Publisher’s version ) (Closed access) Mantle cell lymphoma is a prime example of a well-defined entity based on morphology, phenotype, genetics and also clinical features. Although most patients have an adverse clinical course, some have a better survival than others. The most consistently reported adverse prognostic parameter is a high mitotic rate. Recently, it has been shown that hypermutation in the immunoglobulin heavy-chain gene occurs in a subset of mantle cell lymphomas. It is, however, unclear whether the mutational status is stable over time within a given case, whether hypermutation might be influenced by therapy and how it is related to other relevant biological features of mantle cell lymphoma. In this study, we analyzed 23 typical mantle cell lymphoma cases with respect to mutational status and compared the results with clinicopathological and genetic data to determine whether the presence of mutation indicates a subentity with clinical or pathological relevance. We found somatic hypermutation in 26% of our cases and, interestingly, one case showed ongoing somatic hypermutation. In tumor cells of both mutated and unmutated cases, we found a preferential usage of V(H)3-21 (23%) and V(H)4-34 (19%). No significant correlations were found between mutation status and the other morphological and genetic features analyzed. In conclusion, our results provide additional evidence that mutation status in mantle cell lymphoma is better interpreted as a feature within the spectrum of disease that seems to have little clinical or pathological relevance. |
| وصف الملف: | application/pdf |
| تدمد: | 0893-3952 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a4dcc14504c13dfefb549acca737a9a https://hdl.handle.net/2066/80422 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....2a4dcc14504c13dfefb549acca737a9a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 08933952 |
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