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Physician and Patient Knowledge of Safety and Safe Use Information for Aflibercept in Europe: Evaluation of Risk-Minimization Measures

التفاصيل البيبلوغرافية
العنوان: Physician and Patient Knowledge of Safety and Safe Use Information for Aflibercept in Europe: Evaluation of Risk-Minimization Measures
المؤلفون: Brian Calingaert, Elizabeth Andrews, Ursula Maria Schmidt-Ott, Eric Davenport, Zdravko P. Vassilev, Paul Petraro, Daniel Wolin, Laurie J. Zografos, Kelly Hollis
المصدر: Pharmaceutical Medicine. 33:219-233
بيانات النشر: Springer Science and Business Media LLC, 2019.
سنة النشر: 2019
مصطلحات موضوعية: Adult, Male, Health Knowledge, Attitudes, Practice, medicine.medical_specialty, Cross-sectional study, Recombinant Fusion Proteins, MEDLINE, Angiogenesis Inhibitors, 030226 pharmacology & pharmacy, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Pharmacotherapy, medicine, Humans, media_common.cataloged_instance, Pharmacology (medical), Dosing, European union, Summary of Product Characteristics, Health Education, Aged, media_common, Aflibercept, Aged, 80 and over, Pharmacology, business.industry, Contraindications, Drug, Middle Aged, Europe, Cross-Sectional Studies, Receptors, Vascular Endothelial Growth Factor, Family medicine, Intravitreal Injections, Female, Observational study, Clinical Competence, business, medicine.drug
الوصف: As part of the risk-management plan for aflibercept in the European Union, materials have been developed to educate physicians and patients in Europe on the safe use of aflibercept. The objectives of this study were to measure receipt of the educational materials and to evaluate understanding of key safety information for aflibercept. An observational cross-sectional study among physicians and patients with recent aflibercept experience in France, Germany, Italy, Spain, and the UK was conducted. Eligible physicians and patients completed a brief questionnaire regarding their knowledge of key safety information. Among the 8424 physicians invited to participate in the survey, 428 physicians were eligible, completed the questionnaire, and were included in this analysis. Most physicians reported having received the aflibercept summary of product characteristics (87%) and prescriber guide (77%); approximately half reported receiving the injection procedure video (50%) and patient booklet (54%). Physician knowledge of the most important topics (i.e., side effects; preparing patients for aflibercept injection) was high. Physician knowledge of dosing was high for neovascular (wet) age-related macular degeneration and lower for less commonly prescribed indications. Most physicians knew the contraindications for aflibercept and recognized possible side effects. Among the 874 patients approached about participation in the study, 773 patients were eligible, completed the questionnaire, and were included in the analysis. Patients’ reported receipt was relatively low for the aflibercept patient booklet (38%) and the audio CD (23%). Patient knowledge of the health conditions to discuss with a doctor prior to injection was generally high; knowledge about possible side effects varied. Most patients knew that they should speak to a physician immediately if they experienced a possible side effect of aflibercept. Most physicians reported receiving the summary of product characteristics, prescriber guide, and patient booklet; half reported receiving the intravitreal injection procedure video. Patient receipt of the educational material was variable. Observed patterns of knowledge indicated the greatest knowledge of the most important risks emphasized in the educational material and lower knowledge of more complex or less salient aspects of safe use.
تدمد: 1179-1993
1178-2595
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a4ff74f884bd4c7fb416ea9b9b50153
https://doi.org/10.1007/s40290-019-00279-y
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....2a4ff74f884bd4c7fb416ea9b9b50153
قاعدة البيانات: OpenAIRE
الوصف
تدمد:11791993
11782595