We read with interest the recent paper from Premjeyanth V, et al. about the strong contribution of fecal calprotectin to detect mucosal inflammation in the gastrointestinal tract in patients with skin disorders. To adequately interpret the results of fecal calprotectin levels, Dermatologists have to take into account various issues when prescribing FC measurement in daily practice regarding the conditions of stool collection, sample storage and various factors influencing the measurement of this fecal marker.