التفاصيل البيبلوغرافية
| العنوان: |
Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis |
| المؤلفون: |
A Hemmings, A T Bansal, Lindsey A. Criswell, Laurent Essioux, A. Kenwright, P Cutler, Ruchi Upmanyu, Soren Germer, Ryma Benayed, Olivier Harari, Ann B. Begovich, Mitchell Martin, Kimberly E. Taylor, J Wang, Adam Platt, Janet S. Lee, Jonathan Marchini |
| سنة النشر: |
2016 |
| مصطلحات موضوعية: |
Adult, Male, medicine.drug_class, Disease, Monoclonal antibody, Antibodies, Monoclonal, Humanized, Polymorphism, Single Nucleotide, Arthritis, Rheumatoid, chemistry.chemical_compound, Tocilizumab, Genetics, medicine, Genome-Wide Association Analysis, Humans, Receptor, Pharmacology, business.industry, Interleukin-6, Interleukin, Middle Aged, medicine.disease, Clinical trial, Methotrexate, chemistry, Clinical Trials, Phase III as Topic, Rheumatoid arthritis, Antirheumatic Agents, Immunology, Molecular Medicine, Female, business, Genome-Wide Association Study |
| الوصف: |
Rheumatoid arthritis (RA) is an immune-mediated inflammatory disease affecting the joints. A heterogeneous response to available therapies demonstrates the need to identify those patients likely to benefit from a particular therapy. Our objective was to identify genetic factors associated with response to tocilizumab, a humanized monoclonal antibody targeting the interleukin (IL)-6 receptor, recently approved for treating RA. We report the first genome-wide association study on the response to tocilizumab in 1683 subjects with RA from six clinical studies. Putative associations were identified with eight loci, previously unrecognized as linked to the IL-6 pathway or associated with RA risk. This study suggests that it is unlikely that a major genetic determinant of response exists, and it illustrates the complexity of performing genome-wide association scans in clinical trials. © 2013 Macmillan Publishers Limited. All rights reserved 1470-269X/13. |
| اللغة: |
English |
| تدمد: |
1470-269X |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a8abae4ebe192682e18e6e4930184ed
https://ora.ox.ac.uk/objects/uuid:e69047af-6e04-4bb4-9498-a86405ff7694 |
| حقوق: |
OPEN |
| رقم الأكسشن: |
edsair.doi.dedup.....2a8abae4ebe192682e18e6e4930184ed |
| قاعدة البيانات: |
OpenAIRE |
Find this article in full text from Springer Verlag.