Increased mortality with intensive control in patients with higher baseline SBP and lower Framingham risk
| العنوان: | Increased mortality with intensive control in patients with higher baseline SBP and lower Framingham risk |
|---|---|
| المؤلفون: | Heng-Yu Pan, Hung-Ju Lin, Wen-Jone Chen, Tzung-Dau Wang |
| المصدر: | Journal of Hypertension. 40:978-984 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Male, Cardiovascular Diseases, Heart Disease Risk Factors, Research Design, Risk Factors, Physiology, Internal Medicine, Humans, Female, Renal Insufficiency, Chronic, Cardiology and Cardiovascular Medicine |
| الوصف: | In the Systolic Blood Pressure Intervention Trial (SPRINT), the relative reduction in primary outcome with intensive blood pressure (BP) control was numerically smallest in the highest baseline SBP tertile. In this post hoc analysis of SPRINT, the goal was to explore whether the effects of intensive BP treatment varied among patients with different baseline SBP and cardiovascular risks.Patient-level data from 9361 randomized participants in SPRINT were used. Heterogeneity between treatment and patient characteristics were examined stratified by different baseline SBP levels. Cumulative incidences of primary outcome and all-cause death were compared between treatment groups for patients with baseline SBP at least 160 mmHg and lower Framingham risk.For participants with a baseline SBP of at least 160 mmHg, intensive treatment was associated with a higher rate of all-cause death as compared with standard treatment (1.86 vs. 1.62% per year). After adjustment for age and sex, intensive treatment was associated with significantly increased all-cause death compared with standard treatment [hazard ratio (95% CI) for intensive group: 3.12 (1.00-9.69); P = 0.049] in participants with an SBP of at least 160 mmHg and a Framingham risk score of 31.3% or less (average of median and geometric mean). Patient outcomes were otherwise similar regarding age, use of antihypertensive therapy, cardiovascular disease or chronic kidney disease.Among the SPRINT participants with a baseline SBP of at least 160 mmHg and a lower Framingham risk score, targeting an SBP of less than 120mmHg compared with less than 140mmHg resulted in a significantly higher rate of all-cause death. |
| تدمد: | 1473-5598 0263-6352 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac8ee5a28aca3ea3879ec287f57262f https://doi.org/10.1097/hjh.0000000000003100 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....2ac8ee5a28aca3ea3879ec287f57262f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14735598 02636352 |
|---|