Human Papillomavirus in Urothelial Carcinoma of Bladder: An Indian study
| العنوان: | Human Papillomavirus in Urothelial Carcinoma of Bladder: An Indian study |
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| المؤلفون: | Sunil D. Shenvi, Uttam Mete, Arup K. Mandal, Radha Kanta Ratho, Anuradha Chakraborti, Nandita Kakkar, Mini P Singh |
| المصدر: | International Journal of Applied and Basic Medical Research |
| بيانات النشر: | Medknow Publications & Media Pvt Ltd, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | medicine.medical_specialty, urinary bladder cancer, Urinary bladder, human papillomavirus-18, business.industry, Urology, Disease, Hyperplasia, medicine.disease, female genital diseases and pregnancy complications, medicine.anatomical_structure, Prostate, Human papillomavirus-16, medicine, Etiology, Histopathology, Original Article, Urothelium, Stage (cooking), business, urothelial carcinoma |
| الوصف: | Objectives: To study the role of high-risk human papillomavirus (HPV-16 and HPV-18) types in the causation of urothelial carcinoma of the urinary bladder in Indian population. Methods: 50 patients with Urothelial carcinoma of the urinary bladder were included in the study. Another 10 age-matched subjects who were hospitalized for transurethral resection of prostate for benign prostatic hyperplasia and/or ureterorenoscopy for ureteric stone disease were enrolled as controls. The tissue samples were analyzed for the presence of HPV-16 and HPV-18 DNA by polymerase chain reaction (PCR). The histopathology of the tumor tissue was carried out to assess the grade of the tumor. Results: The mean age of the patients was 54.1 years. A total of 28 (56%) patients had high-grade tumors and 22 (44%) had low-grade disease. T2 or higher stage disease was observed in 18 (36%) patients. All cancerous specimens and control specimens were found to be negative by PCR for the presence of HPV DNA. Conclusion: HPV prevalence in the urothelium is very low irrespective of the stage and grade of the disease, and hence, it is unlikely to be the causative agent for urothelial carcinoma of the urinary bladder in Indian population. However, the role of other HPV types in the etiology of this tumor needs to be clarified. |
| اللغة: | English |
| تدمد: | 2248-9606 2229-516X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae654f28710544dd527692e95290c3b http://europepmc.org/articles/PMC6259300 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....2ae654f28710544dd527692e95290c3b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22489606 2229516X |
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