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Vitamin D and Nonalcoholic Fatty Liver Disease: Bi-directional Mendelian Randomization Analysis

التفاصيل البيبلوغرافية
العنوان: Vitamin D and Nonalcoholic Fatty Liver Disease: Bi-directional Mendelian Randomization Analysis
المؤلفون: Fangzhen Xia, Qin Li, Ningjian Wang, Bing Han, Chi Chen, Jing Cheng, Yingli Lu, Yi Chen, Li Zhao
المصدر: EBioMedicine
EBioMedicine, Vol 28, Iss C, Pp 187-193 (2018)
بيانات النشر: Elsevier, 2018.
سنة النشر: 2018
مصطلحات موضوعية: Epidemiology, BMI, body mass index, lcsh:Medicine, Gastroenterology, chemistry.chemical_compound, 0302 clinical medicine, High-density lipoprotein, 25(OH)D, 25-hydroxyvitamin D, Non-alcoholic Fatty Liver Disease, Risk Factors, LDL, low-density lipoprotein, Nonalcoholic fatty liver disease, Medicine, Vitamin D, lcsh:R5-920, Mendelian Randomization Analysis, Genetic Pleiotropy, General Medicine, SNP, single nucleotide polymorphism, 030211 gastroenterology & hepatology, lcsh:Medicine (General), Research Paper, medicine.medical_specialty, Mendelian randomization analysis, GRS, genetic risk scores, HDL, high-density lipoprotein, 030209 endocrinology & metabolism, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, vitamin D deficiency, 03 medical and health sciences, Internal medicine, Mendelian randomization, Vitamin D and neurology, Humans, Genetic Predisposition to Disease, Genetic Association Studies, business.industry, lcsh:R, nutritional and metabolic diseases, Odds ratio, medicine.disease, digestive system diseases, CI, confidence interval, OR, odds ratio, chemistry, IV, instrumental variables, MR, mendelian randomization, NAFLD, nonalcoholic fatty liver disease, business, HbA1c, glycated hemoglobin A1c
الوصف: Background Vitamin D deficiency is associated with nonalcoholic fatty liver disease (NAFLD) in many cross-sectional studies. However, the causality between them has not been established. We used bi-directional mendelian randomization (MR) analysis to explore the causal relationship between 25-hydroxyvitamin D [25(OH)D] and NAFLD. Methods 9182 participants were included from a survey in East China from 2014 to 2016. We calculated weighted genetic risk scores (GRS) for 25(OH)D concentration and NAFLD based on 25(OH)D-related and NAFLD-related single nucleotide polymorphisms. Presence of liver steatosis was assessed using ultrasound. Instrumental variable was used to measure the causal relationship between them. Results An SD increase in the 25(OH)D GRS was significantly associated with 25(OH)D (β 1.29, 95%CI − 1.54, − 1.04, P
Highlights • The causality between vitamin D and NAFLD was controversial in human beings. • Using mendelian randomization analysis, 25(OH)D and NAFLD are not causally associated. • Long-term vitamin D deficiency may not affect the development of NAFLD.
اللغة: English
تدمد: 2352-3964
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af608f2f5593ab9c7ffa2e5063c17b9
http://europepmc.org/articles/PMC5835542
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....2af608f2f5593ab9c7ffa2e5063c17b9
قاعدة البيانات: OpenAIRE
الوصف
تدمد:23523964