Comparative Proteomic Study Shows the Expression of Hint-1 in Pituitary Adenomas
| العنوان: | Comparative Proteomic Study Shows the Expression of Hint-1 in Pituitary Adenomas |
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| المؤلفون: | Carolina Carrillo-Najar, Juan Luis Gómez-Amador, Alma Ortiz-Plata, Febe Elena Cázares-Raga, Daniel Rembao-Bojórquez, Miguel Ramos-Peek, Fidel de la Cruz Hernández-Hernández, Sergio Zavala-Vega, Martha Lilia Tena-Suck, Noemí Gelista-Herrera |
| المصدر: | Diagnostics, Vol 11, Iss 330, p 330 (2021) Diagnostics Volume 11 Issue 2 |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, VEGF receptors, Clinical Biochemistry, CD34, biological behavior, Biology, Neuroendocrine tumors, medicine.disease_cause, Article, 03 medical and health sciences, 0302 clinical medicine, medicine, Transcription factor, mass spectrometry, lcsh:R5-920, biomarkers, medicine.disease, proteomic analysis, Molecular biology, 030104 developmental biology, classification, 030220 oncology & carcinogenesis, biology.protein, Immunohistochemistry, pituitary adenomas, Signal transduction, Antibody, neuroendocrine tumors, Carcinogenesis, invasive, lcsh:Medicine (General) |
| الوصف: | Pituitary adenomas (PAs) can be unpredictable and aggressive tumors. No reliable markers of their biological behavior have been found. Here, a proteomic analysis was applied to identify proteins in the expression profile between invasive and non-invasive PAs to search for possible biomarkers. A histopathological and immunohistochemical (adenohypophyseal hormones, Ki-67, p53, CD34, VEGF, Flk1 antibodies) analysis was done a proteomic map was evaluated in 64 out of 128 tumors. There were 107 (84%) invasive and 21 (16%) non-invasive PAs 80.5% belonged to III and IV grades of the Hardy–Vezina classification. Invasive PAs (n = 56) showed 105 ± 43 spots 86 ± 32 spots in non-invasive PAs (n = 8) were observed. The 13 most prominent spots were selected and 11 proteins related to neoplastic process in different types of tumors were identified. Hint1 (Histidine triad nucleotide-binding protein 1) high expression in invasive PA was found (11.8 ± 1.4, p = 0.005), especially at high index (> 10 p = 0.0002). High Hint1 expression was found in invasive VEGF positive PA (13.8 ± 2.3, p = 0.005) and in Flk1 positive PA (14.04 ± 2.28, p = 0.006). Hint1 is related to human tumorigenesis by its interaction with signaling pathways and transcription factors. It could be related to invasive behavior in PAs. This is the first report on Hint expression in PAs. More analysis is needed to find out the possible role of Hint in these tumors. |
| وصف الملف: | application/pdf |
| تدمد: | 2075-4418 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af67169388372cfb1700da5dca15730 https://pubmed.ncbi.nlm.nih.gov/33671384 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....2af67169388372cfb1700da5dca15730 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20754418 |
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