Outcome of radioiodine-131 therapy in hyperfunctioning thyroid nodules: a 20 years' retrospective study
| العنوان: | Outcome of radioiodine-131 therapy in hyperfunctioning thyroid nodules: a 20 years' retrospective study |
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| المؤلفون: | Lucia Grasso, Walter Bencivelli, Claudia Ceccarelli, Aldo Pinchera, Paolo Vitti |
| المصدر: | Clinical Endocrinology. 62:331-335 |
| بيانات النشر: | Wiley, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Adult, Male, Thyroid nodules, endocrine system, medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Thyroid Gland, Thyrotropin, chemistry.chemical_element, Iodine, Hyperthyroidism, Iodine Radioisotopes, Endocrinology, Antithyroid Agents, Hypothyroidism, Internal medicine, medicine, Humans, Cumulative incidence, Thyroid Nodule, Radiation Injuries, Survival analysis, Aged, Methimazole, Proportional hazards model, business.industry, Thyroid, Age Factors, Nodule (medicine), Retrospective cohort study, Middle Aged, medicine.disease, Treatment Outcome, medicine.anatomical_structure, chemistry, Disease Progression, Female, medicine.symptom, Epidemiologic Methods, business, hormones, hormone substitutes, and hormone antagonists |
| الوصف: | Summary Objective To investigate the risk of hypothyroidism after radioiodine (131I) treatment for hyperfunctioning thyroid nodules. Design Retrospective analysis of patients treated with 131I for hyperfunctioning thyroid nodules and followed up for a maximum of 20 years. Patients A total of 346 patients treated with 131I in the years 1975–95, for a single hyperfunctioning nodule. Measurements Hypothyroidism was defined as TSH levels > 3·7 mU/l. Kaplan–Meier survival analysis was used to analyse permanence of euthyroidism after 131I. A stepwise Cox proportional hazard model was used to identify factors influencing the progression to hypothyroidism. Results The cumulative incidence of hypothyroidism was 7·6% at 1 year, 28% at 5 years, 46% at 10 years and 60% at 20 years. Age (P |
| تدمد: | 1365-2265 0300-0664 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b0a125b1bfa98a0043f76b7297be53a https://doi.org/10.1111/j.1365-2265.2005.02218.x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....2b0a125b1bfa98a0043f76b7297be53a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652265 03000664 |
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