Hepatitis B Vaccination Response in Hemodialysis Patients: The Impact of Dialysis Shift
| العنوان: | Hepatitis B Vaccination Response in Hemodialysis Patients: The Impact of Dialysis Shift |
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| المؤلفون: | Sharon Rao, Schantel Williams, Franklin W. Maddux, Maggie Han, Xiaoling Ye, Stephan Thijssen, Jeffrey Hymes, Peter Kotanko |
| المصدر: | Blood Purification. 50:628-635 |
| بيانات النشر: | S. Karger AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, medicine.medical_treatment, Population, Context (language use), Renal Dialysis, Internal medicine, medicine, Humans, Hepatitis B Vaccines, Seroconversion, education, Dialysis, Aged, Retrospective Studies, Vaccines, Synthetic, education.field_of_study, business.industry, Vaccination, Hematology, General Medicine, Middle Aged, Hepatitis B, medicine.disease, Nephrology, Kidney Failure, Chronic, Female, Hemodialysis, business, Kidney disease |
| الوصف: | Background/Aims: Hepatitis B (HB) vaccination in hemodialysis patients is important as they are at a higher risk of contracting HB. However, hemodialysis patients have a lower HB seroconversion rate than their healthy counterparts. As better sleep has been associated with better seroconversion in healthy populations and early hemodialysis start has been linked to significant sleep-wake disturbances in hemodialysis patients, we examined if hemodialysis treatment start time is associated with HB vaccination response. Methods: Demographics, standard-of-care clinical, laboratory, and treatment parameters, dialysis shift data, HB antigen status, HB vaccination status, and HB titers were collected from hemodialysis patients in Fresenius clinics from January 2010 to December 2015. Patients in our analysis received 90% of dialysis treatments either before or after 8:30 a.m., were negative for HB antigen, and received a complete series of HB vaccination (Engerix B® or Recombivax HB™). Univariate and multivariate regression models examined whether dialysis start time is a predictor of HB vaccination response. Results: Patients were 65 years old, 57% male, and had a HD vintage of 10 months. Patients whose dialysis treatments started before 8:30 a.m. were more likely to be younger, male, and have a greater dialysis vintage. Patients receiving Engerix B® and starting dialysis before 8:30 a.m. had a significantly higher seroconversion rate compared to patients who started dialysis after 8:30 a.m. Early dialysis start was a significant predictor of seroconversion in univariate and multivariate regression including male gender, but not in multivariate regression including age, neutrophil-to-lymphocyte ratio, and vintage. Conclusion: While better sleep following vaccination is associated with seroconversion in the general population, this is not the case in hemodialysis patients after multivariate adjustment. In the context of end-stage kidney disease, early dialysis start is not a significant predictor of HB vaccination response. The association between objectively measured postvaccination sleep duration and seroconversion rate should be investigated. |
| تدمد: | 1421-9735 0253-5068 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b0de82d22727a5d0b058e737401cb94 https://doi.org/10.1159/000513154 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....2b0de82d22727a5d0b058e737401cb94 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14219735 02535068 |
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