'Real life use' of troponin in the emergency department: a survey of over 3000 cases
| العنوان: | 'Real life use' of troponin in the emergency department: a survey of over 3000 cases |
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| المؤلفون: | Francesca Santi, Alessia Puma, Giorgio Bellomo, Matteo Vidali, Enrica Verzotti, Nicole Cabraz, Gian Carlo Avanzi, Giuseppe Lippi, Alessandro Lupi |
| المصدر: | Biochemia Medica Volume 25 Issue 3 |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, Clinical Biochemistry, Coronary Angiography, Chest pain, Electrocardiography, Patient Admission, Risk Factors, Troponin I, Medicine, Single-Blind Method, hospital, troponin I, acute coronary syndrome, emergency service, hospital, chest pain, Hematologic Tests, biology, medicine.diagnostic_test, Age Factors, musculoskeletal system, Italy, Cardiovascular Diseases, Predictive value of tests, Cardiology, Population study, Female, medicine.symptom, Research Article, medicine.medical_specialty, Acute coronary syndrome, Digestive System Diseases, macromolecular substances, Sensitivity and Specificity, Diagnosis, Differential, Predictive Value of Tests, Internal medicine, Diabetes Mellitus, Humans, Aged, Retrospective Studies, emergency service, business.industry, Biochemistry (medical), Emergency department, Respiration Disorders, medicine.disease, Troponin, biology.protein, business |
| الوصف: | Introduction The aim of this study was to identify clinical variables which may be independently associated with positivity of a cardiac troponin I (cTnI) assay in a large population of patients admitted to the emergency department (ED). Materials and methods 3166 subjects, with at least two troponin I tests ordered within 6 hours in the ED, were studied. Patient data were statistically analyzed to identify clinical associations with increased values of Troponin I. Results Although patients with diagnosis of acute coronary syndrome displayed troponin I values significantly higher than those of other groups, positivity to troponin I (>40 ng/L) was also observed in patients with other clinical conditions. In multivariate analysis, age, elevated heart rate and electrocardiographic changes were independently associated with troponin I positivity at admission. In the whole study population troponin I positivity exhibited high sensitivity and negative predictive value, counterbalanced by low specificity and limited positive predictive value. Conclusions Troponin I positivity should be combined with history and clinical evaluation and cautiously interpreted in the ED, especially in patients exhibiting factors associated with higher troponin I levels such as older age, elevated heart rate or ECG changes. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1330-0962 1846-7482 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b147cadd795d4412b0cb38189ae686c http://hdl.handle.net/11562/929369 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....2b147cadd795d4412b0cb38189ae686c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13300962 18467482 |
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