Injury-Induced Cellular Plasticity Drives Intestinal RegenerationSummary
| العنوان: | Injury-Induced Cellular Plasticity Drives Intestinal RegenerationSummary |
|---|---|
| المؤلفون: | Anne R. Meyer, Monica E. Brown, Patrick S. McGrath, Peter J. Dempsey |
| المصدر: | Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 3, Pp 843-856 (2022) Cellular and Molecular Gastroenterology and Hepatology |
| بيانات النشر: | Elsevier, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | ASCL2, Achaete-scute complex homolog 2, ISC, intestinal stem cells, Cell Plasticity, DCLK1, Doublecortin-like kinase 1, RC799-869, ATOH, atonal bHLH transcription factor 1, Intestinal Regeneration, BMI1, B cell-specific Moloney murine leukemia virus integration site 1, CLU, clusterin, TA, transit-amplifying, Homeostasis, Regeneration, DSS, dextran sodium sulfate, Stem Cell Niche, KRAS, kirsten rat sarcoma viral oncogene homolog, Original Research, EGF, epidermal growth factor, Hepatology, SCF, stem cell factor, DLL, delta like canonical Notch ligand, Gastroenterology, BMP, bone morphogenetic protein, ILC, innate lymphoid cell, LGR5+, leucine-rich repeat-containing G-protein–coupled receptor-5–positive, PDGFRα, platelet derived growth factor receptor alpha, Diseases of the digestive system. Gastroenterology, WNT, wingless-related integration site, FOXL1, forkhead box L1, IL, interleukin, Intestines, Cellular Plasticity, LRC, label-retaining cell, RTK, receptor tyrosine kinase, Intestinal Homeostasis |
| الوصف: | The epithelial lining of the intestine, particularly the stem cell compartment, is affected by harsh conditions in the luminal environment and also is susceptible to genotoxic agents such as radiation and chemotherapy. Therefore, the ability for intestinal epithelial cells to revert to a stem cell state is an important physiological damage response to regenerate the intestinal epithelium at sites of mucosal injury. Many signaling networks involved in maintaining the stem cell niche are activated as part of the damage response to promote cellular plasticity and regeneration. The relative contribution of each cell type and signaling pathway is a critical area of ongoing research, likely dependent on the nature of injury as well as the regional specification within the intestine. Here, we review the current understanding of the multicellular cooperation to restore the intestinal epithelium after damage. |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2c4548990c68ba5ebf409224d926be http://www.sciencedirect.com/science/article/pii/S2352345X21002551 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....2b2c4548990c68ba5ebf409224d926be |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |