New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures
| العنوان: | New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures |
|---|---|
| المؤلفون: | Jonathan D. Rohrer, Nadine Tatton, Chiadi U. Onyike, Michael Gold, Stephen P. Arneric, Ajay Verma, Howard J. Rosen, Rodney Pearlman, Bradley F. Boeve, Carole Ho, Robert N. Schuck, Howard Fillit, Mario Masellis, William J. Marks, Sabrina Paganoni, Earl Ray Dorsey, Kenneth Rockwood, Robert H. Paul, Michael C. Irizarry, Bradford C. Dickerson, Murray Grossman, Holly Soares, Margaret Sutherland, Debra Niehoff, Brian M. Alexander, Susan Dickinson, Frances McFarland, Michael A. Panzara, Howard Feldman, Adam L. Boxer, Edward D. Huey |
| المصدر: | Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 Alzheimers Dement |
| بيانات النشر: | eScholarship, University of California, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Epidemiology, ARTFL, Neurodegenerative, Primary progressive aphasia, 0302 clinical medicine, C9orf72, MAPT, Alzheimer's Disease Related Dementias (ADRD), Clinical Trials as Topic, Health Policy, FTD, Frontotemporal lobar degeneration, Magnetic Resonance Imaging, Clinical trial, Psychiatry and Mental health, Frontotemporal Dementia (FTD), FTLD, Frontotemporal dementia, GRN, medicine.medical_specialty, LEFFTDS, Clinical Trials and Supportive Activities, Clinical Sciences, Article, Progressive supranuclear palsy, 03 medical and health sciences, Cellular and Molecular Neuroscience, Rare Diseases, Developmental Neuroscience, Clinical Research, mental disorders, medicine, Genetics, Acquired Cognitive Impairment, Dementia, Humans, Intensive care medicine, Modalities, business.industry, Neurosciences, nutritional and metabolic diseases, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Biomarker, Congresses as Topic, medicine.disease, nervous system diseases, Brain Disorders, 030104 developmental biology, Geriatrics, Neurology (clinical), Frontotemporal Lobar Degeneration, Geriatrics and Gerontology, Atrophy, business, 030217 neurology & neurosurgery, Biomarkers |
| الوصف: | Introduction Frontotemporal lobar degeneration (FTLD) is the most common form of dementia for those under 60 years of age. Increasing numbers of therapeutics targeting FTLD syndromes are being developed. Methods In March 2018, the Association for Frontotemporal Degeneration convened the Frontotemporal Degeneration Study Group meeting in Washington, DC, to discuss advances in the clinical science of FTLD. Results Challenges exist for conducting clinical trials in FTLD. Two of the greatest challenges are (1) the heterogeneity of FTLD syndromes leading to difficulties in efficiently measuring treatment effects and (2) the rarity of FTLD disorders leading to recruitment challenges. Discussion New personalized endpoints that are clinically meaningful to individuals and their families should be developed. Personalized approaches to analyzing MRI data, development of new fluid biomarkers and wearable technologies will help to improve the power to detect treatment effects in FTLD clinical trials and enable new, clinical trial designs, possibly leveraged from the experience of oncology trials. A computational visualization and analysis platform that can support novel analyses of combined clinical, genetic, imaging, biomarker data with other novel modalities will be critical to the success of these endeavors. |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b53137986dcbcc98368f65c3a2818b4 https://escholarship.org/uc/item/13t6f67b |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....2b53137986dcbcc98368f65c3a2818b4 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |