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Residual risk of mother-to-child transmission of hepatitis B virus infection despite timely birth-dose vaccination in Cameroon (ANRS 12303): a single-centre, longitudinal observational study

التفاصيل البيبلوغرافية
العنوان: Residual risk of mother-to-child transmission of hepatitis B virus infection despite timely birth-dose vaccination in Cameroon (ANRS 12303): a single-centre, longitudinal observational study
المؤلفون: Yusuke Shimakawa, Pascal Veillon, Jacques Birguel, Adeline Pivert, Virginie Sauvage, Hélène Le Guillou-Guillemette, Steven Roger, Richard Njouom, Alexandra Ducancelle, Pierre Amta, Jean Marie Huraux, Jean-Pierre Adoukara, Françoise Lunel-Fabiani
المساهمون: Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology, Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), Université d'Angers (UA), Hôpital de Tokombéré, Institut National de la Transfusion Sanguine [Paris] (INTS), Centre Pasteur du Cameroun, Réseau International des Instituts Pasteur (RIIP), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), This study was funded by Agence nationale de recherches sur le sida et les hépatites virales (ANRS)., Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université (HESAM)-HESAM Université (HESAM)-Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université (HESAM)-HESAM Université (HESAM), Service de Virologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
المصدر: The Lancet global health
The Lancet global health, 2022, 10 (4), pp.e521-e529. ⟨10.1016/S2214-109X(22)00026-2⟩
The Lancet global health, Elsevier, 2022, 10 (4), pp.e521-e529. ⟨10.1016/S2214-109X(22)00026-2⟩
بيانات النشر: HAL CCSD, 2022.
سنة النشر: 2022
مصطلحات موضوعية: Hepatitis B virus, Hepatitis B Surface Antigens, Vaccination, virus diseases, General Medicine, Hepatitis B, Antiviral Agents, Infectious Disease Transmission, Vertical, digestive system diseases, Pregnancy, DNA, Viral, Humans, Female, Hepatitis B Vaccines, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Cameroon, Vaccines, Combined, Pregnancy Complications, Infectious
الوصف: International audience; BackgroundIn sub-Saharan Africa, administration of hepatitis B virus (HBV) birth-dose vaccines remains suboptimal. Evidence is scarce on whether African countries should focus on increasing vaccine coverage or developing strategies incorporating additional measures, such as peripartum antiviral prophylaxis to pregnant women at high risk. To better inform decision makers, we estimated the residual risk of mother-to-child transmission despite HBV birth-dose vaccine in Cameroon.MethodsWe did a single-centre, longitudinal observational study. Pregnant women were systematically screened for HBV surface antigen (HBsAg) at Tokombéré District Hospital (Tokombéré district, Cameroon). Children born to HBsAg-positive mothers in 2009–16 who received the HBV birth-dose vaccine and three subsequent doses of pentavalent vaccine at 6, 10, and 14 weeks were followed up prospectively in 2015–17. In children, capillary blood was obtained for HBsAg rapid test and dried blood spots to quantify HBV DNA concentrations. Venous blood was also collected from HBsAg-positive children. Mother-to-child transmission was confirmed by whole-genome sequencing.FindingsBetween Jan 31, 2009, and Dec 31, 2016, 22 243 (66·8%) of 33 309 pregnant women accepted antenatal HBV screening, of whom 3901 (17·5%) were HBsAg positive. 2004 (51·4%) of 3901 children who were born to HBsAg-positive mothers received the HBV birth-dose vaccine, of whom 1800 (89·8%) also completed the three-dose pentavalent vaccine. In total, the current analysis included 607 children who had a follow-up serosurvey. The prevalence of HBsAg was 5·6% in children who received the birth-dose vaccine in less than 24 h, 7·0% in those who received it 24–47 h after birth, and 16·7% in those who received it 48–96 h after birth (ptrend=0·083). 35 (89·7%) of 39 infected children were born to mothers positive for HBV e antigen with high HBV DNA of 5·3 log10 IU/mL or more. Whole-genome sequencing of HBV in infected mother-child pairs confirmed high identity proportions of 99·97–100%.InterpretationWe documented a substantial risk of mother-to-child transmission despite timely administration of the HBV birth-dose vaccine within 24 h after birth. To reach WHO's elimination targets, peripartum antiviral prophylaxis might be required in parts of Africa, in addition to increasing coverage of the HBV birth-dose vaccine.
اللغة: English
تدمد: 2214-109X
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c1bd07e6be4ad306f758b4fc5b5c543
https://hal-pasteur.archives-ouvertes.fr/pasteur-03697820/file/1-s2.0-S2214109X22000262-main.pdf
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....2c1bd07e6be4ad306f758b4fc5b5c543
قاعدة البيانات: OpenAIRE
الوصف
تدمد:2214109X