Association of Vitamin D Receptor Gene Polymorphisms with Colorectal Cancer in a Saudi Arabian Population
| العنوان: | Association of Vitamin D Receptor Gene Polymorphisms with Colorectal Cancer in a Saudi Arabian Population |
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| المؤلفون: | Alanoud Al Wesaimer, Zainab H. Awadalia, Mansoor-Ali Vaali-Mohammed, Ahmed M. Zubaidi, Khayal Al-Khayal, Maha-Hamadien Abdulla, Rabih Halwani, Zahid Hussain Khan, Omar A Al Obeed |
| المصدر: | PLoS ONE PLoS ONE, Vol 11, Iss 6, p e0155236 (2016) |
| بيانات النشر: | Public Library of Science, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, Male, Linkage disequilibrium, Heredity, lcsh:Medicine, Organic chemistry, Gene Expression, Bioinformatics, Calcitriol receptor, Linkage Disequilibrium, chemistry.chemical_compound, 0302 clinical medicine, Gene Frequency, Genotype, Medicine and Health Sciences, Ethnicities, Vitamin D, lcsh:Science, Deoxyribonucleases, Type II Site-Specific, Aged, 80 and over, education.field_of_study, Multidisciplinary, biology, Vitamins, Middle Aged, FokI, Arabs, Physical sciences, Genetic Mapping, Chemistry, Nutritional deficiencies, 030220 oncology & carcinogenesis, Female, Colorectal Neoplasms, Polymorphism, Restriction Fragment Length, Research Article, Adult, medicine.medical_specialty, TaqI, Population, Saudi Arabia, Single-nucleotide polymorphism, Variant Genotypes, Polymorphism, Single Nucleotide, 03 medical and health sciences, Chemical compounds, Internal medicine, Organic compounds, medicine, Genetics, Humans, Genetic Predisposition to Disease, education, Allele frequency, Alleles, Nutrition, Aged, Colorectal Cancer, Evolutionary Biology, Vitamin D deficiency, Population Biology, business.industry, lcsh:R, Cancers and Neoplasms, Biology and Life Sciences, Human Genetics, Sequence Analysis, DNA, 030104 developmental biology, chemistry, Case-Control Studies, Genetics of Disease, People and Places, biology.protein, Receptors, Calcitriol, lcsh:Q, Population Groupings, business, Population Genetics |
| الوصف: | Background Vitamin D, causally implicated in bone diseases and human malignancies, exerts its effects through binding to the vitamin D receptor (VDR). VDR is a transcription factor modulating the expression of several genes in different pathways. Genetic variants in the VDR gene have been associated with several cancers in different population including colorectal cancer. Objective To assess the association of VDR gene polymorphisms in relation with colorectal cancer (CRC) in a Saudi population. Methods The polymorphisms of VDR gene (BsmI, FokI, ApaI and TaqI) were analyzed by the polymerase chain reaction amplification of segments of interest followed by Sanger sequencing. One hundred diagnosed CRC patients and 100 healthy control subjects that were age and gender matched were recruited. Results We did not observe significant association of any of the four VDR polymorphisms with colorectal cancer risk in the overall analysis. Although not statistically significant, the AA genotype of BsmI conferred about two-fold protection against CRCs compared to the GG genotype. Stratification of the study subjects based on age and gender suggests statistically significant association of CRC with the 'C' allele of ApaI in patients >57 years of age at disease diagnosis and BsmI polymorphism in females. In addition, statistically significant differences were observed for the genotypic distributions of VDR-BsmI, ApaI and TaqI SNPs between Saudi Arabian population and several of the International HapMap project populations. Conclusion Despite the absence of correlation of the examined VDR polymorphisms with CRCs in the combined analysis, ApaI and BsmI loci are statistically significantly associated with CRC in elderly and female patients, respectively. These findings need further validation in larger cohorts prior to utilizing these SNPs as potential screening markers for colorectal cancers in Saudi population. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c1f8d9813210a1fe0e1281c6a1588a0 http://europepmc.org/articles/PMC4911096 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....2c1f8d9813210a1fe0e1281c6a1588a0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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