Effect of sulfadoxine-pyrimethamine chemoprophylaxis in pregnant women on selection of the newP. falciparum dhpsquintuple mutant carrying the I431V mutation
| العنوان: | Effect of sulfadoxine-pyrimethamine chemoprophylaxis in pregnant women on selection of the newP. falciparum dhpsquintuple mutant carrying the I431V mutation |
|---|---|
| المؤلفون: | Olivia Cohen, Emilie Guemas, Sandie Menard, Martial Tsague Kenfack, Carine Talom Ngassa, Xavier Iriart, Marlise Bidzogo Lebobo, Celestin Ondobo Ekae, Carole Eboumbou, Calvin Tiyou Kenmeni, Antoine Berry |
| المصدر: | Journal of Antimicrobial Chemotherapy. 78:665-668 |
| بيانات النشر: | Oxford University Press (OUP), 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Pharmacology, Microbiology (medical), Infectious Diseases, Pharmacology (medical) |
| الوصف: | BackgroundA new mutation in the Plasmodium falciparum dihydropteroate synthetase gene (pfdhps), I431V, has been identified in several countries of Central and West Africa. This mutation is mostly found in association with four other SNPs on pfdhps (S436A, A437G, A581G and A613S), forming a quintuple mutant (vagKgs) and almost always associated with the Plasmodium falciparum dihydrofolate reductase gene (pfdhfr) CirnI (C50R, N51I, S108N) triple mutant. To date, nothing is known about the impact of this new pfdhps genotype on sulfadoxine-pyrimethamine (SP) resistance.ObjectivesWe sought to assess the prevalence of this pfdhps vagKgs quintuple mutant in two groups of pregnant women with malaria, one that took intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) and one that did not.MethodsThe pfdhfr and pfdhps genes from Plasmodium falciparum isolates collected in Yaoundé (Cameroon) from pregnant women with symptomatic malaria under IPTp-SP or not, were sequenced.ResultsOf 159 patients evaluated, 70 had already taken SP during pregnancy and 89 had never taken SP. Only the vagKgs allele was significantly overrepresented in the SP+ group (21.4% versus 3.4%; P ConclusionsWe found a strong overrepresentation of the CirnI/vagKgs haplotype in the IPTp-SP pregnant group, suggesting a high level of resistance of this mutant to SP. This could compromise not only the effectiveness of IPTp-SP but also the seasonal malaria chemoprevention of young children, now widely implemented. |
| تدمد: | 1460-2091 0305-7453 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c58b3351343f5fb77692afdeb608fbe https://doi.org/10.1093/jac/dkac432 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....2c58b3351343f5fb77692afdeb608fbe |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14602091 03057453 |
|---|