Cluster of serogroup W invasive meningococcal disease in a university campus
| العنوان: | Cluster of serogroup W invasive meningococcal disease in a university campus |
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| المؤلفون: | C Tillier, C Jestin, Muhamed-Kheir Taha, H Dupont, I Girard, M Zurbaran, S Tessier, Denise Antona, Daniel Lévy-Bruhl, Outbreak Control Team, F Clinard, C de Bort, Eva Hong, Ala-Eddine Deghmane, Anne-Sophie Barret |
| المساهمون: | Santé publique France - French National Public Health Agency [Saint-Maurice, France], Santé publique France Bourgogne-Franche-Comté, Centre National de Référence des Méningocoques et Haemophilus influenzae - National Reference Center Meningococci and Haemophilus influenzae (CNR), Institut Pasteur [Paris], Agence régionale de santé (ARS) Bourgogne-Franche-Comté, Agence Régionale de la Santé (ARS), We would like to acknowledge the persons who contributed to the epidemiological investigation and the management of this alert at the regional health agency (M. Barba-Vasseur, A. Boulehais, G. Cassière), at the regional unit of the French national public health agency (M. Ciccardini, H. Savolle), at the French national public health agency (B. Coignard, D. Che, D. Heard, P. Bourrier, V. Derrey, A. Gallay, S. Quelet, M. Le Ray, E. Lahaie, D. Pognon), and at the regional hospital (P. Chavanet, A. Dautriche). We also acknowledge all members of the health reserve corps, the hospital staff, and the French armed forces medical service who participated in the vaccination campaign. We would like to thank the staff from the university and schools who contributed to the logistical organization of the campaign (especially MA. Rito who provided computer assistance). We would also like to thank S Bertrand from the Belgian National Reference Center for Neisseria meningitidis for providing WGS data on the third case and A. Terrade and M. Denizon from the French National Reference Center for meningococci for providing technical expertise. Finally, we would like to mention the continuous work from all persons who participate in the surveillance of invasive meningococcal disease in France in regional units (Cire) and at the French national public health agency (C. Campese, C. Maine, Y. Savitch)., Institut Pasteur [Paris] (IP) |
| المصدر: | Médecine et Maladies Infectieuses Médecine et Maladies Infectieuses, Elsevier Masson, 2020, 50 (4), pp.335-341. ⟨10.1016/j.medmal.2019.10.003⟩ Médecine et Maladies Infectieuses, 2020, 50 (4), pp.335-341. ⟨10.1016/j.medmal.2019.10.003⟩ |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Universities, Invasive meningococcal diseases, Serogroup W meningococcus, education, Attack rate, Decision Making, Meningococcal Vaccines, Neisseria meningitidis, [SDV.BID.SPT]Life Sciences [q-bio]/Biodiversity/Systematics, Phylogenetics and taxonomy, Disease cluster, Serogroup, Disease Outbreaks, 03 medical and health sciences, Young Adult, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Individual data, Epidemiology, medicine, Humans, Disease Notification, Phylogeny, 0303 health sciences, Virulence, Méningocoque sérogroupe W, 030306 microbiology, business.industry, Immunization Programs, Incidence, Meningococcal vaccination, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, 3. Good health, University campus, Vaccination, Meningococcal Infections, Infectious Diseases, Disease Hotspot, Infections invasives à méningocoque, Invasive meningococcal disease, Family medicine, Vaccination méningocoque, Mass vaccination, Female, France, Épidémie, business |
| الوصف: | International audience; Introduction : In France, the expansion of an hypervirulent strain causing serogroup W invasive meningococcal disease (MenW) has been observed since 2015/16. We describe a cluster of three MenW cases, causing two deaths, at the end of 2016 in a university campus, and the vaccination campaign which was consequently organized.Methods : Epidemiological and microbiological analyses led a multidisciplinary expertise group to recommend the organization of a mass vaccination campaign using ACWY vaccine targeting more than 30,000 students and staff in the university campus. Individual data on vaccination was collected using the lists of students and staff registered at the university to estimate vaccine coverage.Results : Three MenW cases occurred within a 2-month period among students in different academic courses. All three isolates were identical and belonged to the “UK-2013 strain” phylogenetic branch. The attack rate was 10.8/100,000 students. The vaccination campaign was organized only 15 days after the third case occurred. In total, 13,198 persons were vaccinated. Vaccine coverage was estimated at 41% for students of the university and 35% for university staff.Conclusion : Timely notification of cases to health authorities was essential for the detection of the cluster and the rapid implementation of the vaccination campaign. No further cases occurred in the campus in the year following the vaccination campaign. This episode is the second cluster of MenW caused by the “UK-2013 strain” in a university since 2016.; Introduction : Une souche hypervirulente de méningocoque de sérogroupe W est en expansion en France depuis 2015/16. Cet article décrit un foyer de trois cas d’infection invasive à méningocoque de sérogroupe W (IIMW), à l’origine de deux décès, survenu à la fin de l’année 2016 dans une université, et la campagne de vaccination organisée par les autorités sanitaires.Méthodes : Les analyses épidémiologiques et microbiologiques ont conduit une cellule d’expertise multidisciplinaire à recommander l’organisation d’une campagne de vaccination par les vaccins ACWY ciblant plus de 30 000 étudiants et personnel sur le campus universitaire. Les données individuelles de vaccination ont été recueillies et rapportées aux listes d’étudiants et des personnels inscrits à l’université pour estimer la couverture vaccinale.Résultats : Les trois cas d’IIM W sont survenus dans un délai de 2 mois chez des étudiants dans des filières différentes. Les souches des trois cas étaient identiques (souche UK-2013). Le taux d’attaque était de 10,8/100 000 étudiants. Au total, 13 198 personnes ont été vaccinées. La couverture vaccinale à l’université a été estimée à 41 % pour les étudiants et 35 % pour le personnel.Conclusion : Le signalement réactif des cas a permis de détecter ces cas groupés et de mettre en œuvre rapidement la campagne de vaccination. Aucun nouveau cas d’IIM W n’est survenu dans le campus dans l’année qui a suivi la campagne de vaccination. Cet épisode constitue le deuxième foyer de cas groupés d’IIM W lié à la souche hypervirulente UK-2013 survenant en milieu étudiant depuis 2016. |
| تدمد: | 1769-6690 0399-077X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c71e188e9494e21af36c2a2354ff3ed https://pubmed.ncbi.nlm.nih.gov/31676065 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....2c71e188e9494e21af36c2a2354ff3ed |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17696690 0399077X |
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