Why genes overlap in viruses
| العنوان: | Why genes overlap in viruses |
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| المؤلفون: | Robert Belshaw, Nicola Chirico, Alberto Vianelli |
| المصدر: | Proceedings of the Royal Society B: Biological Sciences |
| بيانات النشر: | The Royal Society, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Genome evolution, Mutation rate, viruses, Genome, Viral, virus, Biology, medicine.disease_cause, Genome, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Capsid, evolution, Genes, Overlapping, medicine, RNA Viruses, Gene, Research Articles, Virus classification, 030304 developmental biology, General Environmental Science, Genetics, 0303 health sciences, Mutation, General Immunology and Microbiology, 030306 microbiology, DNA Viruses, Nucleic acid sequence, RNA, General Medicine, genome compression, Virus Evolution Overlapping genes Mutation rate Capsid, mutation, General Agricultural and Biological Sciences |
| الوصف: | The genomes of most virus species have overlapping genes—two or more proteins coded for by the same nucleotide sequence. Several explanations have been proposed for the evolution of this phenomenon, and we test these by comparing the amount of gene overlap in all known virus species. We conclude that gene overlap is unlikely to have evolved as a way of compressing the genome in response to the harmful effect of mutation because RNA viruses, despite having generally higher mutation rates, have less gene overlap on average than DNA viruses of comparable genome length. However, we do find a negative relationship between overlap proportion and genome length among viruses with icosahedral capsids, but not among those with other capsid types that we consider easier to enlarge in size. Our interpretation is that a physical constraint on genome length by the capsid has led to gene overlap evolving as a mechanism for producing more proteins from the same genome length. We consider that these patterns cannot be explained by other factors, namely the possible roles of overlap in transcription regulation, generating more divergent proteins and the relationship between gene length and genome length. |
| تدمد: | 1471-2954 0962-8452 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca24ad1c182d96f1661da6f9cea0eb3 https://doi.org/10.1098/rspb.2010.1052 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....2ca24ad1c182d96f1661da6f9cea0eb3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712954 09628452 |
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