Intestinal fatty acid‐binding protein is a biomarker for diagnosis of biliary tract infection
| العنوان: | Intestinal fatty acid‐binding protein is a biomarker for diagnosis of biliary tract infection |
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| المؤلفون: | Chih-Jung Chang, Yu-Chieh Weng, Yang-Bor Lu, Yung-Ning Huang, Hui-Shan Hsieh, Wei-Ting Chen, Jung-Chieh Lee, Chih-Kai Yang |
| المصدر: | JGH Open, Vol 5, Iss 10, Pp 1160-1165 (2021) JGH Open: An Open Access Journal of Gastroenterology and Hepatology |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Hepatology, Receiver operating characteristic, business.industry, diagnosis, Gastroenterology, Area under the curve, Zonulin, intestinal fatty acid‐binding protein, Original Articles, Disease, RC799-869, Diseases of the digestive system. Gastroenterology, medicine.disease, Internal medicine, Bacteremia, Cohort, Cholecystitis, Medicine, Biomarker (medicine), biomarker, Original Article, biliary tract infection, business |
| الوصف: | Background and Aim Biliary tract infection (BTI) is an inflammatory disease and commonly associated with bacteremia. Delays in diagnosis or treatment of BTI cause high morbidity and mortality. However, an early diagnosis depends on appropriate clinical investigations. Appropriate biomarkers are urgently needed to improve the BTI diagnostic rate. We hypothesized that intestinal fatty acid‐binding protein (I‐FABP) might be a potential biomarker for BTI diagnosis. Methods We examined data from subjects aged ≥18 years diagnosed with BTI, including cholangitis and cholecystitis, whose blood samples were adequate for I‐FABP and zonulin assessment. We also collected blood samples from healthy volunteers as the control group. We excluded subjects in both groups who received steroids, antibiotics, or probiotics within 1 month before hospital admission (BTI cohort) or participation in this research (controls). The main study endpoint was to compare the diagnostic ability of I‐FABP to detect BTI in comparison with high‐sensitivity C‐reactive protein (hs‐CRP) and zonulin. Results The study collected the data of 51 patients with BTI and 35 healthy subjects. The receiver operating characteristic (ROC) area under the curve (AUC) for I‐FABP was 0.884 (95% confidence interval [CI]: 0.814–0.954), numerically higher than that for hs‐CRP (0.880; 0.785–0.976) and zonulin (0.570; 0.444–0.697). We estimated that the optimal cutoff value of I‐FABP was 2.1 ng/mL (sensitivity: 0.804; specificity: 0.829) for the diagnosis of BTI. Conclusions In summary, this study suggests that I‐FABP may be a potential alternative biomarker to hs‐CRP for diagnosing BTI. Further research should verify the use of I‐FABP as a marker for BTI diagnosis, but also for other inflammatory diseases. Our study revealed the diagnostic performance of intestinal fatty acid‐binding protein (I‐FABP) was comparable to that of C‐reactive protein (CRP) and superior to zonulin for detecting biliary tract infection (BTI). |
| اللغة: | English |
| تدمد: | 2397-9070 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d145546f004b4a1a3746a437bab4fb8 https://doaj.org/article/c0b65283fb56466eac7c361d796251c8 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....2d145546f004b4a1a3746a437bab4fb8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23979070 |
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