The effects of gamma rays on the regeneration of hair follicles are carried over to later hair cycles
| العنوان: | The effects of gamma rays on the regeneration of hair follicles are carried over to later hair cycles |
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| المؤلفون: | Yoshie Ishihara, Sonoe Inoue, Tomohisa Hirobe, Kimihiko Sugaya |
| المصدر: | International Journal of Radiation Biology. 91:957-963 |
| بيانات النشر: | Informa UK Limited, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, Melanocyte, Biology, Andrology, Mice, Immunolabeling, Dermis, Hair cycle, Keratin, otorhinolaryngologic diseases, medicine, Animals, Regeneration, Radiology, Nuclear Medicine and imaging, chemistry.chemical_classification, integumentary system, Radiological and Ultrasound Technology, Keratin-15, Pigmentation, Stem Cells, Hair follicle, Mice, Inbred C57BL, medicine.anatomical_structure, chemistry, Gamma Rays, sense organs, Stem cell, Keratinocyte, Hair Follicle |
| الوصف: | Purpose:The purpose of this study was to determine whether the effects of gamma rays on the regeneration of hair follicles are carried over to later hair cycles. Materials & methods: The whole bodies of C57BL/10JHir mice in the 1st telogen phase were irradiated with 60Co γ-rays. Mice were examined for the effects on hair follicles, including their number, morphology and pigmentation in the 3rd anagen phase. Effects of γ-rays on hair follicle stem cells were investigated by the indirect immunolabeling of keratin 15 (K15). Results: Decreased hair follicle density and induction of curved hair follicles were observed in the dermis of irradiated skin. In addition, white hair and hypopigmented hair bulbs were found. The number of K15-positive hair follicle stem cells in the hair bulge region of irradiated skin appeared to decrease slightly but not significantly. Conclusions: These results suggest that the effects of γ-rays are carried over to a later hair cycle to affect the number, structure and pigmentation of hair follicles in the 3rd anagen phase when stem cells and committed progenitors for keratinocytes and melanocytes are irradiated in the 1st telogen phase. |
| تدمد: | 1362-3095 0955-3002 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1a17a6a0cc1ca964e8e7c9001093ca https://doi.org/10.3109/09553002.2015.1101647 |
| رقم الأكسشن: | edsair.doi.dedup.....2d1a17a6a0cc1ca964e8e7c9001093ca |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 13623095 09553002 |
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