Proximo-distal positional information encoded by an Fgf-regulated gradient of homeodomain transcription factors in the vertebrate limb
| العنوان: | Proximo-distal positional information encoded by an Fgf-regulated gradient of homeodomain transcription factors in the vertebrate limb |
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| المؤلفون: | Alejandra C. López-Delgado, Vanessa Cadenas, Alberto Roselló-Díez, Miguel Torres, Laura Fernandez-de-Manuel, Mark Lewandoski, Fátima Sánchez-Cabo, Giovanna Giovinazzo, Matthew J. Anderson, Irene Delgado |
| المساهمون: | Ministerio de Ciencia, Innovación y Universidades (España), Instituto de Salud Carlos III, Comunidad de Madrid, Fundación ProCNIC, Instituto de Salud Carlos III - ISCIII, Delgado, Irene [0000-0002-0493-8261], López-Delgado, Alejandra C [0000-0003-2187-3938], Roselló-Díez, Alberto [0000-0002-5550-9846], Anderson, Matthew J [0000-0001-9387-5743], Lewandoski, Mark [0000-0002-1066-3735], Torres, Miguel [0000-0003-0906-4767], Apollo - University of Cambridge Repository |
| المصدر: | Repisalud Instituto de Salud Carlos III (ISCIII) Science Advances |
| بيانات النشر: | American Association for the Advancement of Science (AAAS), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 4003 Biomedical Engineering, Biology, Fibroblast growth factor, 03 medical and health sciences, Limb bud, 0302 clinical medicine, biology.animal, mental disorders, Genetics, Limb development, Transcription factor, Research Articles, 030304 developmental biology, 40 Engineering, 0303 health sciences, Multidisciplinary, Vertebrate, SciAdv r-articles, Embryonic stem cell, Cell biology, body regions, Homeobox, 030217 neurology & neurosurgery, psychological phenomena and processes, Research Article, Developmental Biology, 31 Biological Sciences |
| الوصف: | A transcription factor gradient conveys positional information in the vertebrate limb bud. The positional information theory proposes that a coordinate system provides information to embryonic cells about their position and orientation along a patterning axis. Cells interpret this information to produce the appropriate pattern. During development, morphogens and interpreter transcription factors provide this information. We report a gradient of Meis homeodomain transcription factors along the mouse limb bud proximo-distal (PD) axis antiparallel to and shaped by the inhibitory action of distal fibroblast growth factor (FGF). Elimination of Meis results in premature limb distalization and HoxA expression, proximalization of PD segmental borders, and phocomelia. Our results show that Meis transcription factors interpret FGF signaling to convey positional information along the limb bud PD axis. These findings establish a new model for the generation of PD identities in the vertebrate limb and provide a molecular basis for the interpretation of FGF signal gradients during axial patterning. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d2134239de4020c420f50063e713afd https://hdl.handle.net/20.500.12105/10720 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....2d2134239de4020c420f50063e713afd |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |