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Covid-19 and blood groups: ABO antibody levels may also matter

التفاصيل البيبلوغرافية
العنوان: Covid-19 and blood groups: ABO antibody levels may also matter
المؤلفون: Adrien Breiman, Valéry Daubie, Hanane El Kenz, Francis Corazza, Jean-François Fils, Nathalie Ruvoën-Clouet, Marie Deleers, Bhavna Mahadeb, Jacques Jani, Mieke Cannie, Isabelle Barreau, Béatrice Clémenceau, Tatiana Besse, Virginie Doyen, Jacques Le Pendu, Evelyne Maillart, Philippe Van der Linden, Nabil Hayef, Carine Maggetto
المساهمون: Centre Hospitalier Universitaire Brugmann [Bruxelles] (CHU), Université libre de Bruxelles (ULB), Host-Pathogen Interactions in the Regulation of Immune Responses (CRCINA-ÉQUIPE 5), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Immunobiology of Human αβ and γδ T Cells and Immunotherapeutic Applications (CRCINA-ÉQUIPE 1), Ars Statistica [Nivelles, Belgium], Clinical sciences, Supporting clinical sciences, Radiology, Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), Bernardo, Elizabeth
المصدر: International Journal of Infectious Diseases
International Journal of Infectious Diseases, Elsevier, 2020, pp.S1201-9712(20)32549-2. ⟨10.1016/j.ijid.2020.12.025⟩
International Journal of Infectious Diseases, Vol 104, Iss, Pp 242-249 (2021)
International Journal of Infectious Diseases, 2020, pp.S1201-9712(20)32549-2. ⟨10.1016/j.ijid.2020.12.025⟩
بيانات النشر: The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases., 2020.
سنة النشر: 2020
مصطلحات موضوعية: 0301 basic medicine, Male, Epitope, Epitopes, 0302 clinical medicine, hemic and lymphatic diseases, 030212 general & internal medicine, Aged, 80 and over, biology, ABO antibody levels, General Medicine, Covid-19 infection risk, Middle Aged, Galactosyltransferases, 3. Good health, medicine.anatomical_structure, Infectious Diseases, Radiology Nuclear Medicine and imaging, Spike Glycoprotein, Coronavirus, Female, Disease Susceptibility, medicine.symptom, Antibody, Microbiology (medical), Adult, Risk, congenital, hereditary, and neonatal diseases and abnormalities, 030106 microbiology, [SDV.CAN]Life Sciences [q-bio]/Cancer, Lower risk, Asymptomatic, Article, Antibodies, lcsh:Infectious and parasitic diseases, ABO Blood-Group System, 03 medical and health sciences, Young Adult, [SDV.CAN] Life Sciences [q-bio]/Cancer, Polysaccharides, ABO blood group system, Glycosyltransferase, parasitic diseases, medicine, Humans, lcsh:RC109-216, Aged, business.industry, SARS-CoV-2, ABO blood group, COVID-19, Epithelial Cells, Agglutination (biology), Immunoglobulin M, Immunology, biology.protein, ABO antibodies, business, Respiratory tract
الوصف: Highlights • The SARS-CoV-2 spike protein can be tagged with A and/or B blood group antigens. • Upper respiratory tract epithelial cells express A and B antigens. • ABO antibody levels are significantly lower in Covid-19 patients compared to controls. • ABO-related anti-xenoantigen levels do not differ between patients and controls. • People with low levels of ABO antibodies may be at a higher risk of being infected.
Background Susceptibility to Covid-19 has been found to be associated with the ABO blood group, with O type individuals being at a lower risk. However, the underlying mechanism has not been elucidated. Here, we aimed to test the hypothesis that Covid-19 patients might have lower levels of ABO antibodies than non-infected individuals as they could offer some degree of protection. Methods After showing that the viral spike protein harbors the ABO glycan epitopes when produced by cells expressing the relevant glycosyltransferases, like upper respiratory tract epithelial cells, we enrolled 290 patients with Covid-19 and 276 asymptomatic controls to compare their levels of natural ABO blood group antibodies. Results We found significantly lower IgM anti-A + anti-B agglutination scores in blood group O patients (76.93 vs 88.29, P-value = 0.034) and lower levels of anti-B (24.93 vs 30.40, P-value = 0.028) and anti-A antibodies (28.56 vs 36.50, P-value = 0.048) in blood group A and blood group B patients, respectively, compared to controls. Conclusion In this study, we showed that ABO antibody levels are significantly lower in Covid-19 patients compared to controls. These findings could indicate that patients with low levels of ABO antibodies are at higher risk of being infected.
وصف الملف: application/pdf
اللغة: English
تدمد: 1878-3511
1201-9712
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d72efa08d255095ecaf34020197a9b2
http://europepmc.org/articles/PMC7832075
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....2d72efa08d255095ecaf34020197a9b2
قاعدة البيانات: OpenAIRE
الوصف
تدمد:18783511
12019712