Novel insight into the role of clusterin on intraocular pressure regulation by modifying actin polymerization and extracellular matrix remodeling in the trabecular meshwork
| العنوان: | Novel insight into the role of clusterin on intraocular pressure regulation by modifying actin polymerization and extracellular matrix remodeling in the trabecular meshwork |
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| المؤلفون: | Avinash Soundararajan, Ting Wang, Sachin A. Ghag, Min H. Kang, Padmanabhan P. Pattabiraman |
| المصدر: | Journal of Cellular Physiology. 237:3012-3029 |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Physiology, Clinical Biochemistry, Lim Kinases, Cell Biology, Integrin alphaV, Actins, Extracellular Matrix, Polymerization, Mice, Transforming Growth Factor beta2, Clusterin, Trabecular Meshwork, Animals, Humans, Cells, Cultured, Intraocular Pressure |
| الوصف: | This study provides comprehensive mechanistic evidence for the role of clusterin, a stress-response secretory chaperone protein, in the modulation of intraocular pressure (IOP) by regulating the trabecular meshwork (TM) actin cytoskeleton and the extracellular matrix (ECM). The pathological stressors on TM known to elevate IOP significantly lowered clusterin protein levels indicating stress-related clusterin function loss. Small interfering RNA-mediated clusterin loss in human TM cells in vitro induced actin polymerization and stabilization via protein kinase D1, serine/threonine-protein kinase N2 (PRK2), and LIM kinase 1 (LIMK1), and the recruitment and activation of adhesome proteins including paxillin, vinculin, and integrin αV and β5. A complete loss of clusterin as seen in clusterin knockout mice (Clu |
| تدمد: | 1097-4652 0021-9541 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd31960e541d75c2d650e9e919cba6c https://doi.org/10.1002/jcp.30769 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....2dd31960e541d75c2d650e9e919cba6c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10974652 00219541 |
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