Unrecognized Value of Carcinoembryonic Antigen in Recurrent Rectal and Sigmoid Colon Cancer: Case Series
| العنوان: | Unrecognized Value of Carcinoembryonic Antigen in Recurrent Rectal and Sigmoid Colon Cancer: Case Series |
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| المؤلفون: | Myron S Kwong, Sejal Jhatakia, Leonid L Yavorkovsky, Pilar Ivanov |
| المصدر: | The Permanente Journal. 23 |
| بيانات النشر: | The Permanente Federation, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Younger age, Colorectal cancer, Biopsy, Gastroenterology, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Carcinoembryonic antigen, Risk Factors, Internal medicine, Biomarkers, Tumor, medicine, Humans, Aged, Neoplasm Staging, biology, Rectal Neoplasms, business.industry, Cancer, General Medicine, Middle Aged, medicine.disease, Carcinoembryonic Antigen, Sigmoid Neoplasms, Sigmoid colon cancer, Rectosigmoid Region, 030220 oncology & carcinogenesis, Cohort, biology.protein, Female, Clinical Medicine, Neoplasm Recurrence, Local, business, Value (mathematics) |
| الوصف: | INTRODUCTION: Carcinoembryonic antigen (CEA) surveillance is recommended in patients with colorectal cancer for detection of potentially resectable metastases. In patients with appropriate symptoms, a highly increased CEA concentration (> 5 times the upper limit of normal) is considered strongly suggestive of cancer. Despite the recognized value, the test is neither absolutely sensitive nor specific for recurrent cancer. Generally, a greater diagnostic value has been assigned to elevated CEA levels, most commonly greater than 5 ng/mL. Fluctuations within the established normal CEA range are not customarily analyzed. CASE PRESENTATIONS: We report here on 11 patients (8 women, 3 men) who, during the postoperative follow-up period, received a diagnosis of recurrent cancer despite their CEA levels exhibiting very subtle increases. Our cohort shared several similar characteristics such as a nonsmoking status, younger age (median, 52 years at initial diagnosis), and exclusive localization of the cancer to the rectosigmoid region. DISCUSSION: This important clinical observation may expand a prognostic value of CEA in a certain category of patients with colorectal cancer. |
| تدمد: | 1552-5775 1552-5767 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de1b73741fa78327d8e12ff323402ea https://doi.org/10.7812/tpp/18-022 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....2de1b73741fa78327d8e12ff323402ea |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15525775 15525767 |
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