Erythropoietin Protects from Post-Traumatic Edema in the Rat Brain
| العنوان: | Erythropoietin Protects from Post-Traumatic Edema in the Rat Brain |
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| المؤلفون: | Régine Farion, Jean François Payen, Yohan Van De Looij, Olivier Verdonck, Chantal Rémy, Gilles Francony, Christoph Segebarth, Hana Lahrech, Olivier Carle |
| المساهمون: | Neuro-imagerie fonctionnelle et métabolique (ANTE-INSERM U836, équipe 5), Grenoble Institut des Neurosciences (GIN), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Dojat, Michel |
| المصدر: | Journal of Cerebral Blood Flow and Metabolism Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, 2007, 27 (7), pp.1369-76. ⟨10.1038/sj.jcbfm.9600443⟩ |
| بيانات النشر: | SAGE Publications, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | MESH: Brain Edema, Brain Edema, MESH: Magnetic Resonance Imaging, MESH: Recombinant Proteins, 0302 clinical medicine, Edema, MESH: Animals, 0303 health sciences, Neocortex, medicine.diagnostic_test, traumatic brain injury, MESH: Neuroprotective Agents, Magnetic Resonance Imaging, Recombinant Proteins, 3. Good health, Neuroprotective Agents, medicine.anatomical_structure, Neurology, Anesthesia, neuroprotection, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], medicine.symptom, Cardiology and Cardiovascular Medicine, medicine.drug, medicine.medical_specialty, MESH: Rats, Traumatic brain injury, Neuroprotection, Cerebral edema, 03 medical and health sciences, Internal medicine, medicine, Animals, Humans, Effective diffusion coefficient, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Rats, Wistar, Erythropoietin, 030304 developmental biology, MESH: Humans, business.industry, MESH: Erythropoietin, Recombinant, Magnetic resonance imaging, MESH: Rats, Wistar, medicine.disease, Rats, Endocrinology, Brain Injuries, MESH: Brain Injuries, Neurology (clinical), business, 030217 neurology & neurosurgery |
| الوصف: | Erythropoietin (Epo) is gaining interest in various neurological insults as a possible neuroprotective agent. We determined the effects of recombinant human Epo (rhEpo, 5000 IU per kg bw) on brain edema induced in rats by traumatic brain injury (TBI; impact-acceleration model; rhEpo administration 30 mins after injury). Magnetic resonance imaging (MRI) and a gravimetric technique were applied. In the MRI experiments, the apparent diffusion coefficient (ADC) and the tissue T1 relaxation time were measured hourly in the neocortex and caudoputamen, during a 6 h time span after TBI. In the gravimetric experiments, brain water content (BWC) was determined in these two regions, 6 h after TBI. Apparent diffusion coefficient measurements showed that rhEpo decreased brain edema early and durably. Gravimetric measurements showed that rhEpo decreased BWC at H6 in the neocortex as well as in the caudoputamen. No significant differences in ADC, in T1, or in BWC were found between rhEpo treated-TBI rats and sham-operated rats. Our findings show that post-traumatic administration of rhEpo can significantly reduce the development of brain edema in a model of diffuse TBI. Further studies should be conducted to identify the biochemical mechanisms involved in these immediate effects and to assess the use of rhEpo as a possible therapy for post-traumatic brain edema. |
| وصف الملف: | application/pdf |
| تدمد: | 1559-7016 0271-678X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e124facb7abf796dceb936f24bf5161 https://doi.org/10.1038/sj.jcbfm.9600443 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....2e124facb7abf796dceb936f24bf5161 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15597016 0271678X |
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