The use of the SeDeM diagram expert system for the formulation of Captopril SR matrix tablets by direct compression
| العنوان: | The use of the SeDeM diagram expert system for the formulation of Captopril SR matrix tablets by direct compression |
|---|---|
| المؤلفون: | Anna Fàbregas, D. Millán, Josep R. Ticó, J. Saurí, Pilar Pérez-Lozano, Carolina Carrillo, Montserrat Miñarro, Encarna García-Montoya, J. M. Suñé-Negre, Rocío Sarrate |
| المصدر: | Dipòsit Digital de la UB Universidad de Barcelona Recercat. Dipósit de la Recerca de Catalunya instname |
| بيانات النشر: | Elsevier B.V., 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Captopril, Tablets (Medicine), Chemistry, Pharmaceutical, Drug Compounding, Medicació oral, Pharmaceutical Science, Angiotensin-Converting Enzyme Inhibitors, Expert Systems, computer.software_genre, Pharmaceutical technology, Excipients, Matrix (mathematics), Compression (functional analysis), Pressure, Technology, Pharmaceutical, Process engineering, Mathematics, Medicaments d'alliberament retardat, business.industry, Oral medication, Diagram, Quality control, Pólvores (Farmàcia), Expert system, Control de qualitat, Delayed-Action Preparations, business, computer, Design space, Tecnologia farmacèutica, Delayed-action drugs, Tablets, Comprimits (Medicina), Powders (Pharmacy) |
| الوصف: | The SeDeM diagram expert system has been used to study excipients, Captopril and designed formulations for their galenic characterization and to ascertain the critical points of the formula affecting product quality to obtain suitable formulations of Captopril direct compression SR matrix tablets. The application of the SeDeM diagram expert system enables selecting excipients with in order to optimize the formula in the preformulation and formulation studies. The methodology is based on the implementation of ICH Q8, establishing the design space of the formula with the use of experiment design, using the parameters of the SeDeM diagram expert system as system responses. |
| وصف الملف: | application/pdf |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5b8de818709249c2556024ea504ce9 http://hdl.handle.net/2445/53332 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....2e5b8de818709249c2556024ea504ce9 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |