Association of Epstein-Barr virus serological reactivation with transitioning to systemic lupus erythematosus in at risk individuals
| العنوان: | Association of Epstein-Barr virus serological reactivation with transitioning to systemic lupus erythematosus in at risk individuals |
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| المؤلفون: | Neelakshi R. Jog, Diane L. Kamen, Gary S. Gilkeson, John B. Harley, Patrick M. Gaffney, Daniel J. Wallace, Michael H. Weisman, Michael T Harmon, David R. Karp, Judith A. James, Jennifer A. Kelly, Kendra A. Young, Joel M. Guthridge, Melissa E. Munroe, Jill M. Norris |
| المصدر: | Annals of the rheumatic diseases |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Herpesvirus 4, Human, Immunology, Single-nucleotide polymorphism, Autoimmunity, Enzyme-Linked Immunosorbent Assay, medicine.disease_cause, Antibodies, Viral, Systemic Lupus Erythematosus, General Biochemistry, Genetics and Molecular Biology, Virus, Article, Serology, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, immune system diseases, Risk Factors, Internal medicine, Immunology and Allergy, Medicine, Epstein-Barr virus, Humans, Lupus Erythematosus, Systemic, skin and connective tissue diseases, Antigens, Viral, 030304 developmental biology, 030203 arthritis & rheumatology, 0303 health sciences, biology, business.industry, Autoantibody, Herpesviridae Infections, Middle Aged, Epstein–Barr virus, 3. Good health, Case-Control Studies, biology.protein, Female, Antibody, business, Follow-Up Studies |
| الوصف: | ObjectiveSystemic lupus erythematosus (SLE) is a systemic autoimmune disease with unknown aetiology. Epstein-Barr virus (EBV) is an environmental factor associated with SLE. EBV maintains latency in B cells with frequent reactivation measured by antibodies against viral capsid antigen (VCA) and early antigen (EA). In this study, we determined whether EBV reactivation and single nucleotide polymorphisms (SNPs) in EBV-associated host genes are associated with SLE transition.MethodsSLE patient relatives (n=436) who did not have SLE at baseline were recontacted after 6.3 (±3.9) years and evaluated for interim transitioning to SLE (≥4 cumulative American College of Rheumatology criteria); 56 (13%) transitioned to SLE prior to the follow-up visit. At both visits, detailed demographic, environmental, clinical information and blood samples were obtained. Antibodies against viral antigens were measured by ELISA. SNPs in IL10, CR2, TNFAIP3 and CD40 genes were typed by ImmunoChip. Generalised estimating equations were used to test associations between viral antibody levels and transitioning to SLE.ResultsMean baseline VCA IgG (4.879±1.797 vs 3.866±1.795, p=0.0003) and EA IgG (1.192±1.113 vs 0.7774±0.8484, p=0.0236) levels were higher in transitioned compared with autoantibody negative non-transitioned relatives. Increased VCA IgG and EA IgG were associated with transitioning to SLE (OR 1.28 95% CI 1.07 to 1.53, p=0.007, OR 1.43 95% CI 1.06 to 1.93, p=0.02, respectively). Significant interactions were observed between CD40 variant rs48100485 and VCA IgG levels and IL10 variant rs3024493 and VCA IgA levels in transitioning to SLE.ConclusionHeightened serologic reactivation of EBV increases the probability of transitioning to SLE in unaffected SLE relatives. |
| اللغة: | English |
| تدمد: | 1468-2060 0003-4967 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e678f54ddc284de668d8e7e92e1a794 http://europepmc.org/articles/PMC6692217 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....2e678f54ddc284de668d8e7e92e1a794 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14682060 00034967 |
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