Effects of preventive versus 'on-demand' nutritional support on paid labour productivity, physical exercise and performance status during PEG-interferon-containing treatment for hepatitis C
العنوان: | Effects of preventive versus 'on-demand' nutritional support on paid labour productivity, physical exercise and performance status during PEG-interferon-containing treatment for hepatitis C |
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المؤلفون: | Peter D. Siersema, Bart van Hoek, Karel J. van Erpecum, Joop E. Arends, Ellen J. Huisman, Karin M.J. van Nieuwkerk, Suzanne van Meer, Hanneke van Soest |
المصدر: | Clinics and Research in Hepatology and Gastroenterology, 40, 2, pp. 221-9 Clinics and Research in Hepatology and Gastroenterology, 40, 221-9 Clinics and Research in Hepatology and Gastroenterology, 40(2), 221-229 |
بيانات النشر: | Elsevier BV, 2016. |
سنة النشر: | 2016 |
مصطلحات موضوعية: | Male, medicine.medical_specialty, Evening, Physical exercise, Efficiency, Disease, Interferon alpha-2, Antiviral Agents, Polyethylene Glycols, law.invention, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, On demand, Humans, Medicine, Prospective Studies, Karnofsky Performance Status, Exercise, Productivity, Hepatology, Performance status, Nutritional Support, business.industry, Gastroenterology, Interferon-alpha, Hepatitis C, Hepatitis C, Chronic, Middle Aged, medicine.disease, Recombinant Proteins, Nutrition Disorders, 030220 oncology & carcinogenesis, Physical therapy, Female, 030211 gastroenterology & hepatology, business |
الوصف: | Item does not contain fulltext BACKGROUND AND OBJECTIVE: Deterioration of nutritional status during PEG-interferon containing therapy for chronic hepatitis C can be ameliorated by preventive nutritional support. We aimed to explore whether such support also affects paid labour productivity, physical exercise and performance status. METHODS: In this prospective randomized controlled trial (J Hepatol 2012;57:1069-75), 53 patients with chronic hepatitis C had been allocated to "on demand" support (n=26: nutritional intervention if weight loss>5%) or preventive support (n=27: regular dietary advice plus energy- and protein-rich evening snack) during PEG-interferon-containing therapy. Paid labour productivity, physical exercise and performance status were evaluated at baseline, after 24 and (if applicable) after 48weeks of treatment. RESULTS: At baseline, 46% of patients performed paid labour and 62% performed some kind of physical exercise. Furthermore, most patients were able to carry out normal activity with only minor symptoms of disease (mean Karnofsky performance score: 94). Decreases of paid labour productivity (-21% vs. -70%, P=0.003), physical exercise activity (-43% vs. -87%, P=0.005) and Karnofsky performance scores (-12% vs. -24%, P |
وصف الملف: | application/pdf |
تدمد: | 2210-7401 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2edf035f11a4e726834d9f22bc09aba8 https://doi.org/10.1016/j.clinre.2015.06.007 |
حقوق: | OPEN |
رقم الأكسشن: | edsair.doi.dedup.....2edf035f11a4e726834d9f22bc09aba8 |
قاعدة البيانات: | OpenAIRE |
تدمد: | 22107401 |
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