Anti-herpes simplex virus effects of berberine from Coptidis rhizoma, a major component of a Chinese herbal medicine, Ching-Wei-San
| العنوان: | Anti-herpes simplex virus effects of berberine from Coptidis rhizoma, a major component of a Chinese herbal medicine, Ching-Wei-San |
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| المؤلفون: | Ming-Chih Chou, Shih-Shen Lin, Lengsu William Chin, Chi-Chiang Yang, Yu-Wen Cheng, Long-Yau Lin, Ya-Yun Lai, Ming-Yung Chou |
| المصدر: | Archives of Virology. 155:1933-1941 |
| بيانات النشر: | Springer Science and Business Media LLC, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Coptis chinensis, Berberine, viruses, Pharmacology, Biology, Virus Replication, medicine.disease_cause, Antiviral Agents, Virus, chemistry.chemical_compound, Virology, Chlorocebus aethiops, medicine, Animals, Simplexvirus, Medicinal plants, Cytotoxicity, Vero Cells, Chromatography, High Pressure Liquid, Plants, Medicinal, Alkaloid, General Medicine, Antimicrobial, Rhizome, Herpes simplex virus, chemistry, Drugs, Chinese Herbal |
| الوصف: | Berberine is an alkaloid extracted from Coptidis rhizome. Among the individual herbal components of a Chinese herb medicine, Ching-Wei-San, Coptidis Rhizoma has the most potent antimicrobial activity. By high-pressure liquid chromatography, the quantitative analysis of berberine from 6.25-mg/mL (w/v) Coptidis rhizome extract or 50.00-mg/mL (w/v) Ching-Wei-San was determined to be 0.26 mg/mL. To explore the potential use of Ching-Wei-San against herpes simplex virus (HSV) infection, the cytotoxicity, anti-HSV-1 and anti-HSV-2 activity in Vero cells were assayed. The selectivity index of berberine was about 1.2-1.5 times higher than that of Coptidis rhizome extract and Ching-Wei-San. Moreover, the antiviral activities correspond to the content of berberine in the aqueous solution. Berberine may interfere with the viral replication cycle after virus penetration and no later than the viral DNA synthesis step, and its activities were not affected by the preparation processes. Berberine, the natural plants that contain this component, including Coptidis rhizome, and Ching-Wei-San have all shown anti-HSV effects. |
| تدمد: | 1432-8798 0304-8608 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f2e22fe3ae5573e46974eeeff8cb80e https://doi.org/10.1007/s00705-010-0779-9 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....2f2e22fe3ae5573e46974eeeff8cb80e |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14328798 03048608 |
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