Risk of cancer in long‐term levothyroxine users: Retrospective population‐based study
| العنوان: | Risk of cancer in long‐term levothyroxine users: Retrospective population‐based study |
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| المؤلفون: | Hsuan Chia Yang, Yu-Chuan Jack Li, Phung Anh Nguyen, Usman Iqbal, Ching-Huan Wang, Chieh-Chen Wu, Mohaimenul Islam, Tahmina Nasrin Poly |
| المصدر: | Cancer Science |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, long‐term drug use, Cancer Research, medicine.medical_specialty, levothyroxine, Taiwan, Levothyroxine, cancer risk, 03 medical and health sciences, 0302 clinical medicine, Hypothyroidism, association research, Neoplasms, Pancreatic cancer, Internal medicine, medicine, Humans, Aged, Retrospective Studies, case‐control study, business.industry, Thyroid, Confounding, Case-control study, Epidemiology and Prevention, Cancer, Original Articles, General Medicine, Odds ratio, Middle Aged, medicine.disease, Thyroxine, Logistic Models, 030104 developmental biology, medicine.anatomical_structure, Oncology, Case-Control Studies, 030220 oncology & carcinogenesis, Female, Original Article, Skin cancer, business, medicine.drug |
| الوصف: | Levothyroxine is a widely prescribed medication for the treatment of an underactive thyroid. The relationship between levothyroxine use and cancer risk is largely underdetermined. To investigate the magnitude of the possible association between levothyroxine use and cancer risk, this retrospective case‐control study was conducted using Taiwan’s Health and Welfare Data Science Center database. Cases were defined as all patients who were aged ≥20 years and had a first‐time diagnosis for cancer at any site for the period between 2001 and 2011. Multivariable conditional logistic regression models were used to calculate an adjusted odds ratio (AOR) to reduce potential confounding factors. A total of 601 733 cases and 2 406 932 controls were included in the current study. Levothyroxine users showed a 50% higher risk of cancer at any site (AOR: 1.50, 95% CI: 1.46‐1.54; P This retrospective case‐control study analyzed 23 million patients from Taiwan’s claims data. Levothyroxine use was significantly associated with an increased risk of brain, skin, pancreatic, and female breast cancers. |
| تدمد: | 1349-7006 1347-9032 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f4b351dc1230f698a310aa6bd56a88f https://doi.org/10.1111/cas.14908 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....2f4b351dc1230f698a310aa6bd56a88f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13497006 13479032 |
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