Neohesperidin attenuates obesity by altering the composition of the gut microbiota in high‐fat diet‐fed mice
| العنوان: | Neohesperidin attenuates obesity by altering the composition of the gut microbiota in high‐fat diet‐fed mice |
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| المؤلفون: | Yong Liang Wang, Jiang Wei Wu, Bo Xia, Liang Peng, Jun Feng Lu, Hao Liu, Heng Zhang, Xin'e Shi, Meng Qing Zhu |
| المصدر: | The FASEB Journal. 34:12053-12071 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Firmicutes, medicine.medical_treatment, Inflammation, Gut flora, Diet, High-Fat, Systemic inflammation, digestive system, Biochemistry, Mice, Insulin resistance, Internal medicine, Genetics, medicine, Animals, Obesity, Molecular Biology, biology, Bacteroidetes, Hesperidin, Prebiotic, biology.organism_classification, medicine.disease, Gastrointestinal Microbiome, Endocrinology, medicine.symptom, Metabolic syndrome, Dysbiosis, Biotechnology |
| الوصف: | Obesity and related metabolic disorders are associated with intestinal microbiota dysbiosis, disrupted intestinal barrier, and chronic inflammation. Neohesperidin (Neo), a natural polyphenol abundant in citrus fruits, is known for its preventative and therapeutic effects on numerous diseases. Here, we report that Neo administration attenuates weight gain, low-grade inflammation, and insulin resistance in mice fed high-fat diet (HFD). Also, Neo administration substantially restores gut barrier damage, metabolic endotoxemia, and systemic inflammation. Sequencing of 16S rRNA genes in fecal samples revealed that Neo administration reverses HFD-induced intestinal microbiota dysbiosis: an increase in the diversity of gut microbiota and alteration in the composition of intestinal microbiota (particularly in the relative abundances of Bacteroidetes and Firmicutes). Furthermore, systemic antibiotic treatment abolishes the beneficial effects of Neo in body weight control, suggesting that the effect of Neo on obesity attenuation largely depends on the gut microbiota. More importantly, we demonstrate that the impact of Neo on the regulation of obesity could be transferred from Neo-treated mice to HFD-fed mice via fecal microbiota transplantation. Collectively, our data highlight the efficacy of Neo as a prebiotic agent for attenuating obesity, implying a potential mechanism for gut microbiota mediated the beneficial effect of Neo. |
| تدمد: | 1530-6860 0892-6638 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f507351f7cc1aab03ca8e309ec88e43 https://doi.org/10.1096/fj.201903102rr |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....2f507351f7cc1aab03ca8e309ec88e43 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15306860 08926638 |
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